Evaluation of hepatoprotective activity of Syringa oblata leaves ethanol extract with the indicator of glutathione S-transferase A1
Evaluation of hepatoprotective activity of Syringa oblata leaves ethanol extract with the indicator of glutathione S-transferase A1
复制标题
以谷胱甘肽S-转移酶A1为指标评价紫丁香叶乙醇提取物的保肝活性
DOI：
10.1016/j.bjp.2018.05.011
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发表时间：
2018-08-01
期刊：
影响因子：
--
通讯作者：
Liu, Fangping
中科院分区：
文献类型：
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作者：
Li, Ying;Li, Zhi;Liu, Fangping
紫丁香（Syringa oblata Lindl.）木犀科植物木犀草科本研究旨在评价S. oblata叶乙醇提取物对四氯化碳诱导的肝毒性在原代肝细胞和小鼠谷胱甘肽S-转移酶α 1的指标。S.根据肝组织病理学和生化参数以及肝氧化应激标志物评价扁圆叶乙醇提取物。结果表明，四氯化碳负调制生化参数和肝脏抗氧化活性。然而，S.扁圆叶乙醇提取物以剂量依赖性方式恢复改变的血清生化参数和肝脏抗氧化活性。重要的是，S-转移酶α 1的变化趋势与丙氨酸氨基转移酶和天冬氨酸氨基转移酶水平相似，并且S-转移酶α 1建议作为评价S.扁圆叶乙醇提取物。组织学检查显示，相对于对照组，CCl 4引起显著的肝损伤。上述结果表明，S.扁圆叶乙醇提取物对CCl 4诱导的肝损伤具有保护作用，S-转移酶α 1可作为评价扁圆叶乙醇提取物保护作用的指标。扁圆叶乙醇提取物。(C)2018年巴西药妆协会。出版社：Elsevier Editora Ltda
The leaves of Syringa oblata Lindl., Oleaceae, had been extensively used as a folk medicine to treat various infections, heal inflammations, icteric hepatitis and acute mastitis. The study was designed to evaluate the hepatoprotective activity of S. oblata leaves ethanol extract against CCl4-induced hepatotoxicity in primary hepatocytes and mice with the indicator of glutathione S-transferase alpha 1. The hepatoprotective effects of S. oblata leaves ethanol extract were evaluated on the basis of liver histopathology and biochemical parameters as well as hepatic oxidative stress markers. The results showed that CCl4 negatively modulated biochemical parameters and liver antioxidant activities. However, the use of S. oblata leaves ethanol extract restored altered-serum biochemical parameters and liver antioxidant activities in a dose-dependent manner. Importantly, the trends in S-transferase alpha 1 were similar to alanine aminotransferase and aspartate aminotransferase level, and S-transferase alpha 1 was suggested to be a marker for the evaluation of hepatoprotective activity of S. oblata leaves ethanol extract. Histopathological examination showed that CCl4 causes significant hepatic injury relative to control group. The above findings suggested that S. oblata leaves ethanol extract has hepatoprotective effects against CCl4-induced hepatic injury and S-transferase alpha 1 may be an indicator to evaluate the protective effects of S. oblata leaves ethanol extract. (C) 2018 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda.