Expression of adiponectin receptor 1 in olfactory mucosa of mice
Expression of adiponectin receptor 1 in olfactory mucosa of mice
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DOI：
10.1007/s00441-008-0677-6
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发表时间：
2008-11-01
影响因子：
3.6
通讯作者：
Schwarzenbacher, Karin
中科院分区：
文献类型：
--
作者：
Hass, Nicole;Haub, Henriette;Schwarzenbacher, Karin
AdipoR1和AdipoR2是脂肪细胞衍生激素脂联素的受体，脂联素是葡萄糖和脂质代谢的重要调节因子，也与食物摄入和能量稳态的控制有关。在目前的研究中，我们已经证明AdipoR1在小鼠嗅觉粘膜的成熟感觉神经元中表达，其模式与嗅觉标记蛋白相似。AdipoR1在嗅觉粘膜中的表达水平在胚胎发育晚期至成年期间逐渐增加。鼻组织未检测到脂联素的局部表达，提示血清脂联素是嗅觉感觉神经元AdipoR1的配体。由于血清脂联素浓度受脂肪组织质量的调节，肥胖中可见脂联素水平的降低，AdipoR1在嗅觉上皮中的功能似乎与身体的营养状况直接相关，这表明AdipoR1在调节嗅觉系统以满足能量平衡需求方面具有潜在的调节作用。
AdipoR1 and AdipoR2 are receptors for the adipocyte-derived hormone adiponectin, which is an important regulator of glucose and lipid metabolism, and which has also been implicated in the control of food intake and energy homeostasis. In the present study, we have demonstrated that AdipoR1 is expressed in mature sensory neurons of the olfactory mucosa of mice, in a pattern reminiscent of the olfactory marker protein. AdipoR1 expression levels in the olfactory mucosa have been observed to increase gradually during late embryogenesis until adulthood. No local expression of adiponectin has been detected in nasal tissues, indicating that serum adiponectin is the ligand for AdipoR1 in olfactory sensory neurons. As the serum adiponectin concentration is regulated depending on adipose tissue mass, with a reduction of adiponectin levels being seen in obesity, AdipoR1 function in the olfactory epithelium seems to be directly linked to the nutritional status of the body, suggesting a potential modulatory role for AdipoR1 in the adjustment of the olfactory system to energy balance requirements.