Myocardial perfusion reserve: Assessment with multisection, quantitative, first-pass MR imaging
Myocardial perfusion reserve: Assessment with multisection, quantitative, first-pass MR imaging
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DOI：
10.1148/radiology.204.2.9240523
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发表时间：
1997-08-01
期刊：
影响因子：
19.7
通讯作者：
Wilson, RF
中科院分区：
文献类型：
--
作者：
Wilke, N;JeroschHerold, M;Wilson, RF
目得：为了证明用磁共振（MR）首过成像确定心肌血流变化和心肌灌注储备的可行性，通过与动物模型中放射性标记微球血流测量值的比较来验证MR结果，并比较血流动力学不显著的冠状动脉病变和心绞痛患者的冠状动脉血流储备与MR成像时的灌注储备。材料和方法：对8只急性缺血猪和8名成人患者（6名女性，2名男性）进行了心律不齐不敏感、首过、多节段、TI加权MR成像和造影剂增强。在猪中，与MR测量平行获得微球流速测量。结果：在动物实验中，MR灌注指数与微球血流测量值呈线性相关（r = 0.88，P <0.01）。在患者中，局部灌注储备匹配冠状动脉血流储备（线性回归斜率为1.02 +/- 0.09，r = 0.80）。结论：心肌灌注储备可通过首过MR成像进行定量。在微血管功能障碍的患者中，心肌灌注储备与降低的冠状动脉弓储备相匹配。
PURPOSE: To demonstrate the feasibility of determining myocardial blood now changes and the myocardial perfusion reserve with magnetic resonance (MR) first-pass imaging, to validate the MR results by means of comparison with radiolabeled microsphere now measurements in an animal model, and to compare the coronary now reserve with the perfusion reserve at MR imaging in patients with hemodynamically nonsignificant coronary lesions and angina.MATERIALS AND METHODS: Arrhythmia-insensitive, first-pass, multisection, TI-weighted MR imaging with contrast agent enhancement was performed in eight pigs with acute ischemia and in eight adult patients (six women, two men). In the pigs, microsphere now measurements were obtained in parallel with the MR measurements. In the patients, the coronary now reserve was measured with an intracoronary Doppler now ultrasound probe for comparison with the MR perfusion reserve.RESULTS: In the animal studies, there was linear correlation between MR perfusion indexes and the microsphere flow measurements (r = .88, P < .01). In the patients, the regional perfusion reserve matched the coronary flow reserve (linear regression with a slope of 1.02 +/- 0.09, r = .80).CONCLUSION: The myocardial perfusion reserve can be quantified with first-pass MR imaging. In patients with microvascular dysfunction, the myocardial perfusion reserve matches the reduced coronary Bow reserve.