On statistical tests of phylogenetic tree imbalance:: The Sackin and other indices revisited
On statistical tests of phylogenetic tree imbalance:: The Sackin and other indices revisited
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DOI：
10.1016/j.mbs.2005.03.003
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发表时间：
2005-06-01
影响因子：
4.3
通讯作者：
François, O
中科院分区：
文献类型：
--
作者：
Blum, MGB;François, O
我们调查了分布的统计措施，树木不平衡的大型种植园。更具体地说，我们研究的标准化版本的Sackin的索引和给定大小的子树的数量。利用与理论计算机科学结构的联系，我们对Yule树零假设下的极限分布进行了精确的描述。然后计算校正的p值，并根据模拟评估这些统计数据用于测试Yule模型与有偏物种形成模型的统计功效。作为一个例子，测试被应用于HIV-1重建的免疫遗传学。(c)2005年爱思唯尔公司All rights reserved.
We investigate the distribution of statistical measures of tree imbalance in large phylogenies. More specifically, we study normalized versions of the Sackin's index and the number of subtrees of given sizes. Using the connection with structures from theoretical computer science, we provide precise description for the limiting distribution under the null hypothesis of Yule trees. Corrected p-values are then computed, and the statistical power of these statistics for testing the Yule model against a model of biased speciation is evaluated from simulations. As an illustration, the tests are applied to the HIV-1 reconstructed phylogeny. (c) 2005 Elsevier Inc. All rights reserved.