Study of the Expression of Toll-Like Receptors in Different Histological Types of Colorectal Polyps and Their Relationship with Colorectal Cancer
Study of the Expression of Toll-Like Receptors in Different Histological Types of Colorectal Polyps and Their Relationship with Colorectal Cancer
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DOI：
10.1007/s10875-012-9666-3
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发表时间：
2012-08-01
影响因子：
9.1
通讯作者：
Vizoso, Francisco J.
中科院分区：
文献类型：
--
作者：
Eiro, Noemi;Gonzalez, Lucia;Vizoso, Francisco J.
Toll样受体（TLR）信号传导的失调可导致慢性炎症和过度旺盛的修复反应。为探讨TLR在大肠息肉组织中的表达及其临床意义，对70例不同组织学类型的大肠息肉（其中38例为大肠癌）组织中6种TLR的表达水平进行了分析。这些分析通过实时聚合酶链反应、蛋白质印迹和免疫组织化学进行。与其他类型的息肉相比，增生性或腺瘤性息肉中TLR9的表达更高。与其他息肉类型相比，增生性息肉也显示出增加的TLR7水平。TLR7在CC患者的增生性和管状绒毛状腺瘤息肉中的表达较低。CC患者的增生性和绒毛状息肉中TLR 9表达减少。我们的研究结果表明TLR表达可能对结直肠粘膜的恶变具有保护作用。TLR可能代表结直肠息肉中CC风险的病理学标志物。这些因素在结直肠息肉病理中的作用值得进一步研究。
Dysregulation of toll-like receptors (TLR) signaling can result in chronic inflammatory and over-exuberant repair responses. The aim of this study was to investigate the expression and clinical relevance of TLR in colorectal polyps.The expression levels of six TLR were analyzed in 70 patients with different histological types of colorectal polyps, 38 of which developed colorectal carcinoma (CC). These analyses were performed by real-time polymerase chain reaction, western blot, and immunohistochemistry.TLR9 expression was higher in hyperplastic or adenomatous polyps compared to other polyp types. Hyperplastic polyps also showed increased TLR7 levels compared to the other polyp types. TLR7 expression was lower in both hyperplastic and tubulovillous adenoma polyps from patients who developed CC. TLR9 expression was decreased in hyperplastic and villous polyps from patients who developed CC.Our findings suggest a possible protective role of TLR expression against malignant transformation in the colorectal mucosa. TLR may represent a pathological marker of CC risk in colorectal polyps. The role of these factors in the pathology of colorectal polyps deserves further investigation.