Determinants of pulse pressure
Determinants of pulse pressure
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DOI：
10.1161/01.hyp.32.3.556
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发表时间：
1998-09-01
期刊：
影响因子：
8.3
通讯作者：
Westerhof, N
中科院分区：
文献类型：
--
作者：
Stergiopulos, N;Westerhof, N
我们已经探索了确定犬主动脉收缩压（P-s）和舒张压（P-d）的主要动脉参数。测量的主动脉流量被用作动脉系统的2元件Windkessel模型的输入，外周阻力计算为平均压力除以平均流量，总动脉顺应性计算为平均动脉压的衰减时间。将预测值与实测收缩压和舒张压进行比较。在对照条件下，在4个位置（三分叉、三分叉和隔膜之间、隔膜和近端降胸主动脉）和双侧颈动脉闭塞期间，对7只犬进行了测量和计算。在研究的所有条件下，预测的收缩压和舒张压与实验结果非常匹配：P-s，P-wk=（1.000+/-0.0055）P-s，r=0.958，P-d，P-wk=（1.024+/-0.0035）P-d，r=0.995，脉压（PP）的线性回归得到PPwk=（0.99+/-0.016）PP，r=0.911。我们发现，在控制条件下，在主动脉或颈动脉闭塞的存在下，预测的准确性同样良好。脉压与动脉阻力和总动脉顺应性之间的多元回归产生了较差的回归常数（R-2=0.19），这表明单独的2个动脉参数不能解释脉压，流量也是一个重要的决定因素。我们得出结论，对于给定的射血模式（主动脉血流），2个动脉参数，总动脉阻力和总动脉顺应性，足以准确地描述收缩压和舒张压的主动脉。
We have searched to define the major arterial parameters that determine aortic systolic (P-s) and diastolic (P-d) pressure in the dog. Measured aortic flows were used as input to the 2-element windkessel model of the arterial system, with peripheral resistance calculated as mean pressure divided by mean flow and total arterial compliance calculated from the decay time in diastole, The windkessel model yielded an aortic pressure wave from which we obtained the predicted systolic (P-s,P-wk) and diastolic (P-d,P-wk) pressures, These predicted pressures were compared with the measured systolic and diastolic pressures. The measurements and calculations were performed for 7 dogs under control conditions during aortic occlusion at 4 locations (the trifurcation, between the trifurcation and diaphragm, the diaphragm, and the proximal descending thoracic aorta) and during occlusion of both carotid arteries. Under all conditions studied, the predicted systolic and diastolic pressures matched the experimental ones very well: P-s,P-wk=(1.000+/-0.0055) P-s with r=0.958 and P-d,P-wk=(1.024+/-0.0035) P-d with r=0.995, Linear regression for pulse pressure (PP) resulted in PPwk=(0.99+/-0.016) PP with r=0.911. We found the accuracy of prediction equally good under control conditions and in the presence of aortic or carotid artery occlusion. Multiple regression between pulse pressure and arterial resistance and total arterial compliance yielded a poor regression constant (R-2=0.19), suggesting that the 2 arterial parameters alone cannot explain pulse pressure and that flow is an important determinant as well. We conclude that for a given ejection pattern (aortic flow), 2 arterial parameters, total arterial resistance and total arterial compliance, are sufficient to accurately describe systolic and diastolic aortic pressure.