GENDER DIFFERENCES IN SCHIZOPHRENIA
GENDER DIFFERENCES IN SCHIZOPHRENIA
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DOI：
10.1097/00005053-199508000-00005
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发表时间：
1995-08-01
影响因子：
1.9
通讯作者：
BRAFF, DL
中科院分区：
文献类型：
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作者：
ANDIA, AM;ZISOOK, S;BRAFF, DL
在精神分裂症的性别差异评估中，对85例精神分裂症门诊患者（53例男性和32例女性）的病史、症状严重程度、智商、神经认知状态、脑容量损失和皮质不对称性进行了评估。通过婚姻状况、独立生活技能和就业状况评估社会功能。发现了显著的性别差异，因为女性服用的抗精神病药物剂量较低，并且比男性更经常符合偏执型和紊乱型精神分裂症亚型的标准。妇女也受到更好的教育，更经常结婚，独立生活和就业。在现年龄、症状严重程度、神经认知功能或临床磁共振成像扫描读数方面没有发现性别差异。我们的研究结果表明，即使两组之间的症状和神经认知状态相当，妇女也可能比男子经历较少的精神分裂症的不良人际关系和心理社会后果。然而，更广泛的调查是必要的，以更好地了解性别差异的病理生理或社会机制的作用。
In an assessment of gender differences in schizophrenia, 85 outpatients (53 men and 32 women) with schizophrenia were evaluated for illness history, symptom severity, IQ, neurocognitive status, cerebral volume loss, and cortical asymmetry. Social functioning was assessed using marital status, independent living skills, and employment status. Significant gender differences were found, as women were on lower doses of neuroleptic medications and more frequently met criteria for paranoid and disorganized subtypes of schizophrenia than men. Women also were better educated and more often married, living independently, and employed. No gender differences were found in present age, symptom severity, neurocognitive functioning, or clinical magnetic resonance imaging scan readings. Our findings suggest that; women may experience less of the adverse interpersonal and psychosocial consequences of schizophrenia than men, even when symptom and neurocognitive status is equivalent between groups. However, more extensive investigations are warranted to better understand the role of pathophysiological or social mechanisms in gender differences.