Silk Fibroin Bioinks for Digital Light Processing (DLP) 3D Bioprinting
Silk Fibroin Bioinks for Digital Light Processing (DLP) 3D Bioprinting
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DOI：
10.1007/978-981-15-3258-0_4
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Park, Chan Hum
中科院分区：
文献类型：
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作者：
Kim, Soon Hee;Kim, Do Yeon;Park, Chan Hum
三维（3D）生物打印已经成为组织工程领域中具有高度影响力的技术，以实现细胞、生长因子和生物材料的快速和精确的空间图案化。生物墨水是3D生物打印的主要因素之一，水凝胶是生物墨水用于3D生物打印的优秀基质类型。最近，通过数字光处理（DLP）的立体光刻生物打印，允许复杂结构的高空间分辨率和快速打印时间吸引了许多研究。然而，与用于其他生物打印机的生物墨水相比，少数生物墨水已被应用于DLP生物打印。我们开发了一种基于丝素蛋白的新型生物墨水，由于其良好的生物学和生物化学特性，已被广泛应用于生物医学领域。在本章中，我们概述了丝素蛋白的基本原理以及丝素蛋白作为印刷材料的各种应用。并对用于DLP生物打印机的丝素生物墨水的制备和性能进行了讨论。
Three-dimensional (3D) bioprinting has been a highly influential technology in the field of tissue engineering to enable speedy and precise spatial patterning of cells, growth factors, and biomaterials. Bioink is one of the main factors in 3D bioprinting, and hydrogels are excellent matrix type by means of bioinks for 3D bioprinting. Recently, stereolithographic bioprinting via digital light processing (DLP) that allows high spatial resolution and rapid printing time of complex structures has attracted many studies. However, a small number of bioinks have been applied to DLP bioprinting in comparison with bioinks for other bioprinters. We developed a novel bioink based on silk fibroin that has been extensively used in biomedical fields due to its positive biological and biochemical properties as biomaterials. In this chapter, we summarized the silk fibroin basics and various applications of silk fibroin as printing material. Also, fabrication and performance of silk-based bioink for DLP bioprinter were discussed.