The role of dendritic cell subsets in selection between tolerance and immunity
The role of dendritic cell subsets in selection between tolerance and immunity
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DOI：
10.1046/j.1440-1711.2002.01116.x
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发表时间：
2002-10-01
影响因子：
4
通讯作者：
Carbone, FR
中科院分区：
文献类型：
--
作者：
Belz, GT;Heath, WR;Carbone, FR
树突状细胞（DC）被认为是大自然的佐剂。它们是幼稚T细胞的强效刺激物和原发性免疫反应的关键诱导剂。近年来，人们已经清楚地认识到它们也可以在T细胞耐受性的发展中发挥核心作用。进一步使我们对DC函数的理解复杂化的是认识到DC不能再被视为一种均匀的细胞类型。相反，它们是由截然不同的细胞群组成的复杂混合体。近年来，驱动耐受性和免疫相互冲突的免疫结果的机制一直是密切关注的主题，最近的研究是关于各种DC亚群如何参与这些事件。在这里，我们回顾了最近的实验，这些实验提供了对DC亚群如何控制T细胞激活结果的见解，并在免疫和耐受性诱导之间进行选择。
Dendritic cells (DC) are considered nature's adjuvants. They are potent stimulators of naive T cells and key inducers of primary immune responses. In recent times it has become clear that they can also play a central role in the development of T cell tolerance. Further complicating our understanding of DC function is the realization that DC can no longer be viewed as a homogeneous cell type. Rather, they exist as a complex mixture of strikingly different cell populations. The mechanisms that drive the conflicting immunological outcomes of tolerance and immunity have been the subject of intense scrutiny in recent years, most recently in terms of how the various DC subsets are involved in these events. Here we review recent experiments that provide insights into how DC subsets control the outcome of T cell activation and in so doing select between immunity and tolerance induction.