Post translational modification of Parkin.
Post translational modification of Parkin.
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DOI：
10.1186/s13062-017-0176-3
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发表时间：
2017-02-21
期刊：
影响因子：
5.5
通讯作者：
Ziviani E
中科院分区：
文献类型：
--
作者：
Chakraborty J;Basso V;Ziviani E
编码E3泛素连接酶帕金的基因突变与一种罕见的常见常染色体隐性遗传性帕金森综合征有关。尽管对帕金蛋白进行了数十年的研究，其结构最近已经解决，但对导致帕金激活的特定信号通路知之甚少。帕金的活性范围从线粒体质量控制到肿瘤抑制和应激保护;因此，人们很容易假设帕金对细胞生理学的广泛影响可能是不同翻译后修饰的结果，这些修饰可以通过平衡的相反事件来控制。来自不同物种的帕金的序列比对表明跨帕金直系同源物的结构域之间的高度同源性，并鉴定高度保守的氨基酸残基，如果修饰，则影响帕金功能。在这篇综述中，我们总结了翻译后修饰已被证明会影响帕金活性和稳定性的研究结果。本文由Konstanze F. Winklhofer和托马斯西门教授。两位评审员都是由卢卡·佩莱格里尼教授提名的。
Mutations in the gene encoding for the E3 ubiquitin ligase Parkin are associated to a rare form of familiar autosomal recessive Parkinsonism. Despite decades of research on the Parkin protein, whose structure has been recently solved, little is known about the specific signalling pathways that lead to Parkin activation. Parkin activity spans from mitochondria quality control to tumor suppression and stress protection; it is thus tempting to hypothesize that the broad impact of Parkin on cellular physiology might be the result of different post translational modifications that can be controlled by balanced opposing events. Sequence alignment of Parkin from different species indicates high homology between domains across Parkin orthologs and identifies highly conserved amino acid residues that, if modified, impinge on Parkin functions. In this review, we summarize findings on post translational modifications that have been shown to affect Parkin activity and stability. This article was reviewed by Prof. Dr. Konstanze F. Winklhofer and by Prof. Thomas Simmen. Both reviewers have been nominated by Professor Luca Pellegrini.