Proteoglycans in health and disease: structures and functions.
Proteoglycans in health and disease: structures and functions.
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DOI：
10.1042/bj2360001
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发表时间：
1986-05
期刊：
影响因子：
--
通讯作者：
A. Poole
中科院分区：
文献类型：
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作者：
A. Poole
一般组成和结构蛋白聚糖是由蛋白质骨架组成的大分子，其上共价连接有GAG链和N和/或O-连接的寡糖（图1）。PG的GAG链组成及其与核心蛋白的连接见表1。在角膜基质中，KS通过用于将糖蛋白和PG的复合型和高甘露糖寡糖连接到蛋白质的键连接到蛋白质上[118]。所有PG的核心蛋白还结合有0-连接寡糖和/或复合型N-连接寡糖[81]。PG的核心蛋白是这些分子中研究得最少的成分：这在下面讨论。到目前为止，仅为一个PG建立了完整的核心蛋白序列[20]。鉴于PG结构和组成的相当复杂性，为了组织PG的逻辑分类方案，我们不仅需要知道组成GAG的身份，而且首先需要知道核心蛋白序列。现在我们将讨论不同类型的PG及其已知或怀疑的功能。
General composition and structure Proteoglycans are macromolecules which consist of a protein backbone to which GAG chain(s) and Nand/or 0-linked oligosaccharides are covalently attached (Fig. 1). The composition of GAG chains of PGs and their linkages to core proteins are described in Table 1. In the corneal stroma, KS is attached to protein by a linkage of the kind used to attach the complex-type and highmannose oligosaccharides of glycoproteins and PGs to protein [118]. To the core proteins of all PGs are also bound 0-linked oligosaccharides and/or complex-type N-linked oligosaccharides [81]. The core proteins of PGs have been the least well studied components of these molecules: this is discussed below. The complete core protein sequence has so far been established for only one PG [20]. In view of the considerable complexity ofPG structure and composition, for us to organize a logical classification scheme for PGs we need to know not only the identities of the constituent GAGs but also, and primarily, the core-protein sequences. We will now discuss the different types of PGs and their known or suspected functions.