Cerebral arterial responses to induced hypertension following subarachnoid hemorrhage in the monkey.
Cerebral arterial responses to induced hypertension following subarachnoid hemorrhage in the monkey.
复制标题
猴蛛网膜下腔出血后脑动脉对诱发高血压的反应。
DOI：
10.3171/jns.1978.49.1.0075
复制
发表时间：
1978
影响因子：
4.1
通讯作者：
M. Grace
中科院分区：
文献类型：
--
作者：
D. Boisvert;T. Overton;B. Weir;M. Grace
在恒河猴中测量局部脑血流量（rCBF）、血管造影脑动脉口径和脑脊液（CSF）压力，以确定实验诱导的蛛网膜下腔出血（SAH）对脑动脉对血压分级升高反应的影响。这些测量也在通过将人工CSF注射到脑空间中而经受模拟SAH的对照组猴中进行。在蛛网膜下腔注射血液或人工CSF之前，平均动脉血压（MABP）分级升高至基线值以上40%至50%的水平对rCBF没有影响。主要脑动脉收缩，CSF压力保持不变。在注射人工CSF后观察到类似的反应。当接受蛛网膜下腔注射血液的动物MABP增加时，rCBF增加，并与主要脑动脉扩张和CSF压力中度增加相关。这些结果表明，脑动脉对血压升高的反应可能是异常的存在蛛网膜下腔血液。脑动脉反应性异常、血压变化和血管痉挛联合收割机共同决定SAH后脑灌注水平的方式被假定。
Regional cerebral blood flow (rCBF), angiographic cerebral arterial caliber, and cerebrospinal fluid (CSF) pressure were measured in rhesus monkeys to determine the effect of experimentally induced subarachnoid hemorrhage (SAH) on cerebral arterial responses to graded increases in blood pressure. These measurements were also performed in a control group of monkeys subjected to a mock SAH by injection of artificial CSF into the cerebral space. Before subarachnoid injection of blood or artificial CSF, graded increases in mean arterial blood pressure (MABP) to a level 40% to 50% above baseline values had no effect on rCBF. The major cerebral arteries constricted and CSF pressure remained unchanged. Similar responses were observed after injections of artificial CSF. When MABP was increased in animals that had been subjected to subarachnoid injection of blood, rCBF increased and was associated with dilatation of the major cerebral arteries and moderate increases in CSF pressure. These results demonstrate that cerebral arterial responses to increases in blood pressure may be abnormal in the presence of subarachnoid blood. The manner in which abnormal cerebral arterial reactivity, changes in blood pressure, and vasospasm combine to determine the level of cerebral perfusion following SAH is postulated.