Zika virus: History, emergence, biology, and prospects for control.
Zika virus: History, emergence, biology, and prospects for control.
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DOI：
10.1016/j.antiviral.2016.03.010
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发表时间：
2016-06
影响因子：
7.6
通讯作者：
Vasilakis N
中科院分区：
文献类型：
--
作者：
Weaver SC;Costa F;Garcia-Blanco MA;Ko AI;Ribeiro GS;Saade G;Shi PY;Vasilakis N
寨卡病毒（ZIKV）是一种以前不为人知的黄病毒，与登革热、西尼罗河病毒、日本脑炎和黄热病病毒密切相关，自2007年以来爆发性出现，在密克罗尼西亚、南太平洋和最近的美洲引起一系列流行病。ZIKV在撒哈拉以南非洲的假定进化之后，在遥远的过去传播到亚洲，并且可能多次出现在涉及伊蚊（Stegomyia）spp的城市传播周期中。蚊子和人类的放大主机，伴随着一个相对温和的登革热样疾病。最近在南太平洋和美洲爆发的感染人数前所未有，可能导致足够的ZIKV感染，以注意到相对罕见的先天性小头畸形和格林-巴利综合征。另一种假设是亚洲谱系ZIKV毒株的表型变化导致这些疾病结果。在这里，我们回顾了通过以病媒为中心的方法控制正在发生的疫情的潜在策略以及疫苗和治疗方法的发展前景。
Zika virus (ZIKV), a previously obscure flavivirus closely related to dengue, West Nile, Japanese encephalitis and yellow fever viruses, has emerged explosively since 2007 to cause a series of epidemics in Micronesia, the South Pacific, and most recently the Americas. After its putative evolution in sub-Saharan Africa, ZIKV spread in the distant past to Asia and has probably emerged on multiple occasions into urban transmission cycles involving Aedes (Stegomyia) spp. mosquitoes and human amplification hosts, accompanied by a relatively mild dengue-like illness. The unprecedented numbers of people infected during recent outbreaks in the South Pacific and the Americas may have resulted in enough ZIKV infections to notice relatively rare congenital microcephaly and Guillain–Barré syndromes. Another hypothesis is that phenotypic changes in Asian lineage ZIKV strains led to these disease outcomes. Here, we review potential strategies to control the ongoing outbreak through vector-centric approaches as well as the prospects for the development of vaccines and therapeutics.