Effects of Dental Treatment and Single Application of a 40% Chlorhexidine Varnish on Mutans Streptococci in Young Children under Intravenous Anaesthesia
Effects of Dental Treatment and Single Application of a 40% Chlorhexidine Varnish on Mutans Streptococci in Young Children under Intravenous Anaesthesia
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效果%20of%20牙科%20治疗%20和%20单次%20应用%20of%20a%2040%%20洗必泰%20清漆%20on%20变异%20链球菌%20in%20年轻%20儿童%20under%20静脉%20麻醉
DOI：
10.1159/000016601
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发表时间：
2000
期刊：
影响因子：
4.2
通讯作者：
J. Veerkamp
中科院分区：
文献类型：
--
作者：
D.M. van Maele;J. D. de Soet;K. Weerheijm;H. Groen;J. Veerkamp
临床研究表明，应用高浓度洗必泰清漆可减少变形链球菌的数量，从而降低龋齿风险。本研究的目的是确定牙齿治疗对变形链球菌（MS）和乳酸杆菌（LB）水平的影响，以及单次应用40%洗必泰清漆（EC 40）对MS水平的额外影响。选择了23名年龄在5岁以下的儿童进行全面的牙齿治疗。在这23名儿童中（平均dmf-s27. 1，SD 19.3），11名儿童有奶瓶龋。平均糖暴露量为6.4。受试者被随机分为两组，每组人数大致相等。一组在牙科治疗后接受EC 40应用，而另一组仅接受完整的牙科治疗，两者均使用丙泊酚作为单一药物进行静脉麻醉。在牙科治疗之前采集未刺激的唾液样品和牙菌斑样品。6周后重复受试者的唾液和牙菌斑采样。分离MS和LB并计数。在合并的菌斑样本中，患有106个以上MS的儿童数量在牙科治疗后6周从8个显著减少到2个。EC 40对唾液MS无明显影响，两组间及治疗前后唾液MS数无明显变化。治疗前（21名儿童）和治疗后6周（17名儿童）的LB值保持在高于104/ml唾液的高水平。这项研究的结果表明，牙科治疗导致菌斑MS的显著抑制，而单次应用EC 40在6周后没有显示出显著的额外抑制。
Clinical studies suggest that application of a highly concentrated chlorhexidine varnish results in a decrease in the number of mutans streptococci and thereby a decrease in the caries risks. The aim of this study was to determine the effect of dental treatment on the levels of mutans streptococci (MS) and lactobacilli (LB) and the additional effect of a single application of 40% chlorhexidine varnish (EC40) on the level of MS. Twenty–three children under the age of 5 years scheduled for full dental treatment were selected. Of these 23 children (mean dmf–s 27.1, SD 19.3), 11 children had nursing bottle caries. The mean sugar exposure was 6.4. Subjects were randomly distributed into two groups of approximately equal size. One group received an EC40 application after dental treatment, while the other group received only full dental treatment, both with intravenous anaesthesia with propofol as a single drug. An unstimulated saliva sample and a plaque sample were taken prior to dental treatment. The saliva and plaque sampling of the subjects was repeated after 6 weeks. MS and LB were isolated and counted. The number of children harbouring more than 106 MS in a pooled plaque sample decreased significantly from 8 to 2 children 6 weeks after dental treatment. No additional effect of EC40 was found. The number of salivary MS did not change significantly between the groups or before and after treatment. The figures for LB remained at a high level of more than 104/ml saliva before (21 children) and 6 weeks after treatment (17 children). The results of this study indicate that dental treatment results in a significant suppression of plaque MS, while a single application of EC40 showed no significant additional suppression after 6 weeks.