Dietary fat and its relationship to large bowel cancer.
Dietary fat and its relationship to large bowel cancer.
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作者：
B. Reddy
流行病学数据为大肠癌发生的病因学因素提供了线索。膳食脂肪摄入过多往往会促进结肠癌的发生。代谢流行病学研究表明，高膳食脂肪会影响肠道细菌的代谢活动以及可能充当结肠肿瘤促进剂的次级胆汁酸的水平。动物模型研究表明，膳食脂肪总量（而不是脂肪类型）在结肠癌发生中发挥促进作用。
Epidemiological data have provided clues to the etiological factors involved in large bowel cancer development. High intake of dietary fat tends to promote colon carcinogenesis. Studies in metabolic epidemiology have shown that the high dietary fat affects the metabolic activity of gut bacteria as well as the levels of secondary bile acids that may act as tumor promoters for the colon. Animal model studies indicate that total dietary fat, rather than type of fat, exerts a promoting role in colon carcinogenesis.