CONNECTIVE-TISSUE IN AGING LUNG
CONNECTIVE-TISSUE IN AGING LUNG
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DOI：
10.1159/000213148
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发表时间：
1983-01-01
期刊：
影响因子：
3.5
通讯作者：
SAMPOGNARO, S
中科院分区：
文献类型：
--
作者：
ANDREOTTI, L;BUSSOTTI, A;SAMPOGNARO, S
胶原蛋白，弹性蛋白和结构糖蛋白进行了测量，在21个完整的肺采取死后检查后突然死亡的[人类]受试者，年龄从15-83 [yr]。数据表示为每立方厘米肺周围实质的毫克数，膨胀并固定在25 cm H2O的标准压力下，以排除参考干燥组织重量的缺陷。膨胀的干燥肺实质的体积/重量比随着年龄的增长显着增加;胶原蛋白含量下降，胶原蛋白/弹性蛋白的比例，而弹性蛋白含量没有表现出任何显着的相关性与年龄。老年肺的生化、形态和功能数据一致。
Collagen, elastin and structural glycoproteins were measured in 21 intact lungs taken at postmortem examination after sudden death from [human] subjects aged from 15-83 [yr]. Data were expressed as milligrams per cubic centimeter of lung peripheral parenchyma inflated and fixed at the standard pressure of 25 cm H2O, to exclude the pitfall of referring to dried tissue weight. The volume/weight ratio of inflated dried lung parenchyma increased significantly with aging; collagen content decreased and so did the collagen/elastin ratio, while elastin content did not show any significant correlation with age. Biochemical, morphological and functional data on the senile lung agree well.