EPITHELIAL-CELLS EXPRESSING ABERRANT MHC CLASS-II DETERMINANTS CAN PRESENT ANTIGEN TO CLONED HUMAN T-CELLS
EPITHELIAL-CELLS EXPRESSING ABERRANT MHC CLASS-II DETERMINANTS CAN PRESENT ANTIGEN TO CLONED HUMAN T-CELLS
复制标题
DOI：
10.1038/312639a0
复制
发表时间：
1984-01-01
期刊：
影响因子：
64.8
通讯作者：
FELDMANN, M
中科院分区：
文献类型：
--
作者：
LONDEI, M;LAMB, JR;FELDMANN, M
诱导免疫应答的第一步，无论是体液还是细胞介导的，都需要抗原呈递细胞和限制在主要组织相容性复合体（MHC）1，2的T淋巴细胞之间的相互作用。这些细胞总是表达MHC II类分子（人的HLA-D区和小鼠的Ia区），其被与抗原片段相关的辅助/诱导子亚群的T细胞识别3，4。有趣的是，在某些病理条件下5 -8，例如在自身免疫性疾病如甲状腺炎5和糖尿病性胰岛炎6中，II类分子可以在通常不表达它们的上皮细胞上表达。我们推测这些细胞可能能够将其表面自身抗原呈递给T细胞，并且该过程可能对自身免疫的诱导和维持至关重要9。这一假设的关键检验是确定携带MHC II类分子的上皮细胞（II类+细胞）是否可以将抗原呈递给T细胞。我们在这里报告，II类+甲状腺滤泡上皮细胞（甲状腺细胞）确实可以提出病毒肽抗原克隆的人T细胞。
The first step in the induction of immune responses, whether humoral or cell mediated, requires the interaction between antigen-presenting cells and T lymphocytes restricted at the major histo-compatibility complex (MHC)1,2. These cells invariably express MHC class II molecules (HLA-D region in man and Ia in mouse) which are recognized by T cells of the helper/inducer subset in association with antigen fragments3,4. Interestingly, in certain pathological conditions5–8, for example in autoimmune diseases such as thyroiditis5and diabetic insulitis6, class II molecules may be expressed on epithelial cells that normally do not express them. We speculated that these cells may be able to present their surface autoantigens to T cells, and that this process may be crucial to the induction and maintenance of autoimmunity9. A critical test of this hypothesis would be to determine whether epithelial cells bearing MHC class II molecules (class II+cells) can present antigen to T cells. We report here that class II+thyroid follicular epithelial cells (thyrocytes) can indeed present viral peptide antigens to cloned human T cells.