Functional capacity of the liver after two-thirds partial hepatectomy in the rat.
Functional capacity of the liver after two-thirds partial hepatectomy in the rat.
复制标题
大鼠三分之二部分肝切除术后肝脏的功能能力。
DOI：
10.1016/s0039-6060(97)90058-1
复制
发表时间：
1997
期刊：
影响因子：
3.8
通讯作者：
Kensho Sanjo
中科院分区：
文献类型：
--
作者：
Masaji Hashimoto;Kensho Sanjo
背景大鼠肝部分切除术后肝细胞增殖已被广泛研究。尽管已经在该大鼠模型中研究了DNA合成和形态恢复，但残肝在再生过程中的功能能力尚未阐明。方法我们测量了大鼠三分之二肝切除后不同时间段的吲哚菁绿色消失率（ICG-k）和血清氨基比林（CLamp）。根据残肝重量、增殖细胞核抗原标记指数和再生肝DNA含量评价肝切除术后肝脏的形态学恢复。ICG-K和CLamp的系列变化后三分之二肝切除术进行了比较的程度的形态restoration.ResultsICG-K和CLamp减少了三分之一的大鼠后三分之二肝切除术。肝切除术后残肝重量恢复率较稳定，但ICG-k和CLamp在术后36小时左右最低。ICG-k的恢复是可比的肝脏重量，但CLamp的恢复是delayed.ConclusionsFunctional肝容量是最小的实质细胞有丝分裂过程中再生肝。在大鼠中，三分之二肝切除后的功能恢复比形态恢复延迟。
BackgroundLiver cell proliferation after partial hepatectomy in rats has been thoroughly investigated. Although DNA synthesis and morphologic restoration have been studied in this rat model, the functional capacity of the remnant liver during regeneration has not been elucidated.MethodsWe measured the indocyanine green disappearance rate (ICG-k) and serum aminopyrine (CLamp) in rats at various intervals after two-thirds hepatectomy. Morphologic restoration of the liver after hepatectomy was evaluated on the basis of remnant liver weight, proliferating cell nuclear antigen labeling index, and the DNA content of the regenerating liver. Serial changes in ICG-k and CLamp after two-thirds hepatectomy were compared with the degree of morphologic restoration.ResultsICG-k and CLamp were reduced by one third in rats after two-thirds hepatectomy. Although the rate of restoration of remnant liver weight was steady after hepatectomy, ICG-k and CLamp were lowest about 36 hours after hepatectomy. The restoration of ICG-k was comparable to that of liver weight, but the restoration of CLamp was delayed.ConclusionsFunctional liver capacity was minimal during parenchymal cell mitosis in the regenerating liver. Functional restoration after two-thirds hepatectomy was delayed in comparison with morphologic restoration in rat.