Multiphysics of Prionlike Diseases: Progression and Atrophy
Multiphysics of Prionlike Diseases: Progression and Atrophy
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朊病毒样疾病的多物理场：进展和萎缩
DOI：
10.1103/physrevlett.121.158101
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发表时间：
2018
影响因子：
8.6
通讯作者：
Goriely, Alain
中科院分区：
文献类型：
--
作者：
Weickenmeier, Johannes;Kuhl, Ellen;Goriely, Alain
许多神经退行性疾病与毒性蛋白在整个大脑中的传播和积累有关。由这些有毒蛋白质的聚集体产生的损伤进一步导致细胞死亡和加速的组织萎缩。这些疾病中的一些的显著特征是它们的特征性模式和演变，导致神经病理学可见的良好编码的疾病阶段，并且与各种认知缺陷和病理学相关。在这里，我们模拟的各向异性传播和积累的有毒蛋白质在全脑几何。我们发现，相同的模型与不同的初始播种区再现不同的朊病毒样疾病的特征演变。我们还恢复了总毒性蛋白负荷的预期演变。最后，我们将我们的运输模型耦合到机械萎缩模型，以获得神经退行性疾病中发现的典型变性模式。
Many neurodegenerative diseases are related to the propagation and accumulation of toxic proteins throughout the brain. The lesions created by aggregates of these toxic proteins further lead to cell death and accelerated tissue atrophy. A striking feature of some of these diseases is their characteristic pattern and evolution, leading to well-codified disease stages visible to neuropathology and associated with various cognitive deficits and pathologies. Here, we simulate the anisotropic propagation and accumulation of toxic proteins in full brain geometry. We show that the same model with different initial seeding zones reproduces the characteristic evolution of different prionlike diseases. We also recover the expected evolution of the total toxic protein load. Finally, we couple our transport model to a mechanical atrophy model to obtain the typical degeneration patterns found in neurodegenerative diseases.