Local field potential oscillations in primate cerebellar cortex: Synchronization with cerebral cortex during active and passive expectancy
Local field potential oscillations in primate cerebellar cortex: Synchronization with cerebral cortex during active and passive expectancy
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DOI：
10.1152/jn.00080.2004
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发表时间：
2005-04-01
影响因子：
2.5
通讯作者：
Lamarre, Y
中科院分区：
文献类型：
--
作者：
Courtemanche, R;Lamarre, Y
许多大脑区域，如小脑、初级体感皮层（SI）和初级运动皮层（MI），相互作用产生协调的动作。感觉运动脑区的局部场电位（LFPs）同步与运动表现有关，通常通过10至25赫兹的振荡LFPs。猕猴小脑旁脉小叶（PM）也显示出10至25赫兹的LFP振荡，这种振荡在刺激-反应杠杆按压任务中被调节以获得奖励（主动条件），但也在类似的时间刺激-奖励关系（被动条件）中被调节，尽管不同。这项研究的重点是在主动（左或右杠杆按压）和被动条件下灵长类动物SI或MI和PM小脑同时的UP活动。结果显示在小脑中有类似的10- 25赫兹振荡的调制模式。在活动状态下（左手或右手），MI和SI，刺激开始后下降，恢复，运动开始后再次下降。在被动条件下，当猴子不动但获得奖励时，所有3个区域都表现出振荡特征，振荡在刺激开始后增加，并持续到奖励，这表明这些振荡在被动期望中起作用。然而，在主动条件下，小脑LFPs和SI LFPs之间的同步性比被动条件下更高，而感兴趣的手的同步性最高。当猴子必须按下杠杆时，这种更大的PM-SI同步可能代表了一种形式的脑-小脑交流，也许是为了完成任务而服务于体感处理；PM-MI同步对于所使用的手的选择性较小，并且可能携带更一般类型的信息。
Many brain regions, such as the cerebellum, primary somatosensory cortex (SI), and primary motor cortex (MI), interact to produce coordinated actions. Synchronization of local field potentials (LFPs) in sensorimotor cerebral areas has been related to motor performance, often through 10- to 25-Hz oscillatory LFPs. The macaque cerebellar paramedian lobule (PM) also shows 10- to 25-Hz LFP oscillations, which are modulated in a stimulus-response lever press task to get reward (active condition), but also, albeit differently, in a similarly timed stimulus-reward relation (passive condition). This study focuses on simultaneous UP activity in primate SI or MI and the PM cerebellum during the active (left- or right-hand lever presses) and passive conditions. Results show a similar modulation pattern of 10- to 25-Hz oscillations in the cerebellum. MI, and SI during the active condition (left or right hand), decreasing after stimulus onset, returning, and again decreasing after movement onset. In the passive condition, when the monkey did not move but got reward, all 3 areas show an oscillatory profile where oscillations increase after stimulus onset and last until reward, denoting a role for these oscillations in passive expectancy. However, synchronization between cerebellar LFPs and SI LFPs is higher during the active condition than during the passive condition, and highest for the interested hand. This greater PM-SI synchronization, when the monkey had to press the lever, could represent a form of cerebro-cerebellar communication, perhaps to serve somatosensory processing to accomplish the task; PM-MI synchronization was less selective for the hand used and might carry a more general type of information.