Modeling Human Respiratory Viral Infections in the Cotton Rat (Sigmodon hispidus).
Modeling Human Respiratory Viral Infections in the Cotton Rat (Sigmodon hispidus).
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DOI：
10.4172/jaa.1000093
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发表时间：
2014-03-03
期刊：
影响因子：
--
通讯作者：
Kajon A
中科院分区：
文献类型：
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作者：
Blanco JC;Boukhvalova MS;Perez DR;Vogel SN;Kajon A
For over three decades, cotton rats have been a preferred model for human Respiratory Syncytial Virus (RSV) infection and pathogenesis, and a reliable model for an impressive list of human respiratory pathogens including adenoviruses, para influenza virus, measles, and human metapneumo virus. The most significant contribution of the cotton rat to biomedical research has been the development of anti-RSV antibodies for prophylactic use in high-risk infants. More recently, however, the cotton rat model has been further explored as a model for infection with other respiratory viral pathogens including influenza and rhinovirus.Together with RSV, these viruses inflict the greatest impact on the human respiratory health.This review will focus on the characteristics of these new models and their potential contribution to the development of new therapies.
