The Role of Interleukin-1β in Destruction of Transplanted Islets.
The Role of Interleukin-1β in Destruction of Transplanted Islets.
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Interleukin-1β 在移植胰岛破坏中的作用
DOI：
10.1177/0963689720934413
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发表时间：
2020-01
影响因子：
3.3
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Chen C;Rong P;Yang M;Ma X;Feng Z;Wang W
胰岛移植是治疗1型糖尿病的一种很有前途的β细胞替代疗法，与标准胰岛素治疗相比，它可以减少葡萄糖不稳定和低血糖发作。尽管在这一领域取得了巨大进展，但在长期成功的移植结果方面仍然存在挑战。单供胰岛移植后胰岛素依赖率仍然很低。已有研究表明，胰岛相关炎症反应是导致移植后早期胰岛损伤和移植物丢失的主要原因。白细胞介素-1 β（IL-1β）的产生被认为是胰腺获取、胰岛分离和胰岛移植过程中的主要有害炎症事件之一。有证据表明，先天性免疫应答通过Toll样受体和NACHT结构域-亮氨酸-富含重复序列和含PYD的蛋白3炎性体的活性上调，这些是一系列信号传导事件的起点，这些信号传导事件驱动胰岛移植中过量的IL-1β产生。本文综述了近年来IL-1β在胰岛移植中的研究进展，并讨论了IL-1β在胰岛移植中的应用策略。
Islet transplantation is a promising β-cell replacement therapy for type 1 diabetes, which can reduce glucose lability and hypoglycemic episodes compared with standard insulin therapy. Despite the tremendous progress made in this field, challenges remain in terms of long-term successful transplant outcomes. The insulin independence rate remains low after islet transplantation from one donor pancreas. It has been reported that the islet-related inflammatory response is the main cause of early islet damage and graft loss after transplantation. The production of interleukin-1β (IL-1β) has considered to be one of the primary harmful inflammatory events during pancreatic procurement, islet isolation, and islet transplantation. Evidence suggests that the innate immune response is upregulated through the activity of Toll-like receptors and The NACHT Domain-Leucine-Rich Repeat and PYD-containing Protein 3 inflammasome, which are the starting points for a series of signaling events that drive excessive IL-1β production in islet transplantation. In this review, we show recent contributions to the advancement of knowledge of IL-1β in islet transplantation and discuss several strategies targeting IL-1β for improving islet engraftment.
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影响因子：
3.3
作者：
Danobeitia JS;Hanson MS;Chlebeck P;Park E;Sperger JM;Schwarznau A;Fernandez LA
通讯作者：
Fernandez LA
影响因子：
3.3
作者：
Dong，Huansheng;Zhang，Yong;Wang，Hongjun
通讯作者：
Wang，Hongjun
影响因子：
8.8
作者：
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通讯作者：
Yin, D. P.
影响因子：
5.8
作者：
Courtade, Jaques A.;Klimek-Abercrombie, Agnieszka M.;Verchere, C. Bruce
通讯作者：
Verchere, C. Bruce
影响因子：
6.2
作者：
Citro, Antonio;Cantarelli, Elisa;Piemonti, Lorenzo
通讯作者：
Piemonti, Lorenzo