Acetylation Enhances the Promoting Role of AIB1 in Breast Cancer Cell Proliferation.
Acetylation Enhances the Promoting Role of AIB1 in Breast Cancer Cell Proliferation.
复制标题
乙酰化增强 AIB1 在乳腺癌细胞增殖中的促进作用
DOI：
10.14348/molcells.2016.2267
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发表时间：
2016-09
影响因子：
3.8
通讯作者：
Yan S
中科院分区：
文献类型：
--
作者：
You D;Zhao H;Wang Y;Jiao Y;Lu M;Yan S
乳腺癌中扩增的癌基因核受体辅激活因子1（AIB 1）是一种转录辅激活因子，在包括乳腺癌在内的各种人类癌症中过表达。然而，调节AIB1功能的分子机制在很大程度上仍然未知。在这项研究中，我们提出的证据表明，AIB1是乙酰化的MOF在人类乳腺癌细胞。此外，我们还发现AIB1的乙酰化增强了其促进乳腺癌细胞增殖的功能。我们进一步表明，AIB1的乙酰化是E2F1将其募集到E2F1靶基因所必需的。更重要的是，我们发现与非癌细胞相比，人类乳腺癌细胞中AIB 1的乙酰化水平大大升高。总的来说，我们的研究结果揭示了调节乳腺癌中AIB1功能的分子机制。
The oncogene nuclear receptor coactivator amplified in breast cancer 1 (AIB1) is a transcriptional coactivator, which is overexpressed in various types of human cancers, including breast cancer. However, the molecular mechanisms regulating AIB1 function remain largely unknown. In this study, we present evidence demonstrating that AIB1 is acetylated by MOF in human breast cancer cells. Moreover, we also found that the acetylation of AIB1 enhances its function in promoting breast cancer cell proliferation. We further showed that the acetylation of AIB1 is required for its recruitment to E2F1 target genes by E2F1. More importantly, we found that the acetylation levels of AIB1 are greatly elevated in human breast cancer cells compared with that in non-cancerous cells. Collectively, our results shed light on the molecular mechanisms that regulate AIB1 function in breast cancer.