Low absolute CD4+ T cell counts in peripheral blood are associated with inferior survival in follicular lymphoma
Low absolute CD4+ T cell counts in peripheral blood are associated with inferior survival in follicular lymphoma
复制标题
外周血中 CD4( ) T 细胞绝对计数低与滤泡性淋巴瘤的较差生存率相关
DOI：
10.1007/s13277-016-5124-9
复制
发表时间：
2016-09-01
期刊：
影响因子：
--
通讯作者：
Xu, Wei
中科院分区：
文献类型：
--
作者：
He, Lu;Liang, Jin-Hua;Xu, Wei
宿主免疫和肿瘤微环境显着影响滤泡性淋巴瘤（FL）的结果。淋巴细胞减少症已被确定为FL的一个负面预后因素。然而，有有限的数据，外周血T淋巴细胞亚群的预后价值，特别是绝对CD 4（+）T细胞计数（ACD 4C）在FL。我们研究了127例连续FL患者，以调查是否外周血ACD 4C或绝对单核细胞（AMC）在诊断FL预后的影响。在我们的队列中，通过单变量分析，低ACD 4C和高AMC均与较低的无进展生存期（PFS）（分别为P = 0.021和P = 0.013）和较低的总生存期（OS）（分别为P = 0.020和P = 0.005）相关。多变量分析显示，仅低ACD 4C在PFS恶化（风险比，2.811; 95%置信区间，1.137-6.950; P = 0.025）和OS缩短（风险比，3.393; 95%置信区间，1.037-11.105; P = 0.043）中具有统计学显著性，与FLIPI-2无关。血液ACD 4C的评价可能是一个有用的指标，在以前未经治疗的FL患者的结果。
Host immunity and tumor microenvironment significantly influence follicular lymphoma (FL) outcomes. Lymphopenia has been identified as a negative prognostic factor for FL. However, there is limited data regarding prognostic value of peripheral blood T lymphocyte subsets, especially absolute CD4(+) T cell counts (ACD4C) in FL. We studied 127 consecutive FL patients to investigate whether peripheral blood ACD4C or absolute monocytes (AMC) at diagnosis had an impact on FL prognosis. In our cohort, both low ACD4C and high AMC were the parameters associated with inferior progression-free survival (PFS) (P = 0.021 and P = 0.013, respectively) and inferior overall survival (OS) (P = 0.020 and P = 0.005, respectively) by univariate analysis. Multivariate analysis revealed that only low ACD4C was statistically significant in worse PFS (hazard ratio, 2.811; 95 % confidence interval, 1.137-6.950; P = 0.025) and shorter OS (hazard ratio, 3.393; 95 % confidence interval, 1.037-11.105; P = 0.043) independent of FLIPI-2. Evaluation of blood ACD4C could be a useful indicator of outcome in previously untreated FL patients.