Zinc deficiency in Chronic Kidney Disease: Is there a Relationship with Adipose Tissue and Atherosclerosis?
Zinc deficiency in Chronic Kidney Disease: Is there a Relationship with Adipose Tissue and Atherosclerosis?
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DOI：
10.1007/s12011-009-8504-9
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发表时间：
2010-06-01
影响因子：
3.9
通讯作者：
Mafra, Denise
中科院分区：
文献类型：
--
作者：
Lobo, Julie Calixto;Machado Torres, Joao Paulo;Mafra, Denise
加速的动脉粥样硬化性疾病引起的心血管并发症是慢性肾脏病(CKD)患者发病率和死亡率的主要原因。这些患者存在多种动脉粥样硬化危险因素，被认为是传统的，也有非传统的危险因素，如炎症和氧化应激。这些并发症也见于肥胖，在肥胖症中，内皮功能障碍是动脉粥样硬化的早期阶段之一。在CKD患者和肥胖者中，微量金属缺乏对这一过程的影响尚未得到很好的研究，尽管微量元素缺乏的影响，特别是锌(锌)的影响，可能具有重要的临床意义。这篇简短的综述描述了锌的功能以及这种微量元素在动脉粥样硬化过程中的各自作用，特别是对患有慢性肾脏疾病的肥胖患者。
Cardiovascular complications caused by an accelerated atherosclerotic disease consist the major cause of morbidity and mortality in patients with chronic kidney disease (CKD). These patients present multiple atherosclerotic risk factors, considered traditional, as well as nontraditional risk factors such as inflammation and oxidative stress. These complications are also seen in obesity, in which endothelial dysfunction is one of the early stages of atherosclerosis. The impact of trace metal deficiencies on this process is not well studied in patients with CKD and in obese people, although the influence of trace elements depletion, particularly zinc (Zn), may have significant clinical implications. This brief review describes the functions of Zn as well as the respective role of this trace element in atherosclerosis processes, with a particular emphasis on obese patients with chronic kidney disease.