Protein self-assembly: A new frontier in cell signaling.
Protein self-assembly: A new frontier in cell signaling.
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DOI：
10.1016/j.ceb.2020.12.013
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发表时间：
2021-04
影响因子：
7.5
通讯作者：
Jarosz DF
中科院分区：
文献类型：
--
作者：
Saad S;Jarosz DF
长期以来，朊病毒被认为是改变范式的，但很罕见，最近在生命的各个领域都发现了朊病毒。能够驱动这种形式的自组装的蛋白质序列在真核生物蛋白质组中非常常见，它们富含参与信息流和信号转导的蛋白质。虽然朊病毒被认为是蛋白质折叠中随机错误的结果，但最近的研究表明朊病毒的形成可能是由确定的细胞信号启动的受控过程。许多存在于正常的生物环境中，但对于大多数用于询问蛋白质组的技术是不可见的。在这里，我们回顾的机制，蛋白质自组装可以创建一个稳定的记录过去的刺激，改变适应性反应，以及朊病毒的行为是如何控制的信号过程。我们触及了这对正常生物功能和调节的不同影响，从真菌的耐药性到人类的先天免疫反应。最后，我们讨论了潜在的朊病毒结构域的转录因子和RNA结合蛋白编排遗传基因表达的变化，响应瞬时信号，如在发展过程中。
Long viewed as paradigm-shifting, but rare, prions have recently been discovered in all domains of life. Protein sequences that can drive this form of self-assembly are strikingly common in eukaryotic proteomes, where they are enriched in proteins involved in information flow and signal transduction. Although prions were thought to be a consequence of random errors in protein folding, recent studies suggest that prion formation can be a controlled process initiated by defined cellular signals. Many are present in normal biological contexts yet are invisible to most technologies used to interrogate the proteome. Here we review mechanisms by which protein self-assembly can create a stable record of past stimuli, altering adaptive responses, and how prion behavior is controlled by signaling processes. We touch on the diverse implications that this has for normal biological function and regulation, ranging from drug resistance in fungi to the innate immune response in humans. Finally, we discuss the potential for prion domains in transcription factors and RNA binding proteins to orchestrate heritable gene expression changes in response to transient signals, such as during development.
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DOI：
10.15252/embj.201798896
发表时间：
2018-08-15
期刊：
The EMBO journal
影响因子：
--
作者：
Arnold CD;Nemčko F;Woodfin AR;Wienerroither S;Vlasova A;Schleiffer A;Pagani M;Rath M;Stark A
通讯作者：
Stark A
新发现的朊病毒与酿酒酵母中染色质重塑因子 Swi1 相关
影响因子：
30.8
作者：
Du, Zhiqiang;Park, Kyung-Won;Li, Liming
通讯作者：
Li, Liming
影响因子：
8.8
作者：
Batlle, Cristina;Yang, Peiguo;Ventura, Salvador
通讯作者：
Ventura, Salvador
影响因子：
56.9
作者：
Franzmann, Titus M.;Jahnel, Marcus;Alberti, Simon
通讯作者：
Alberti, Simon
影响因子：
64.5
作者：
Boija A;Klein IA;Sabari BR;Dall'Agnese A;Coffey EL;Zamudio AV;Li CH;Shrinivas K;Manteiga JC;Hannett NM;Abraham BJ;Afeyan LK;Guo YE;Rimel JK;Fant CB;Schuijers J;Lee TI;Taatjes DJ;Young RA
通讯作者：
Young RA