MAPK overexpression is associated with anthracycline resistance and increased risk for recurrence in patients with triple-negative breast cancer
MAPK overexpression is associated with anthracycline resistance and increased risk for recurrence in patients with triple-negative breast cancer
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DOI：
10.1093/annonc/mdm522
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发表时间：
2008-04-01
影响因子：
50.5
通讯作者：
Topuz, E.
中科院分区：
文献类型：
--
作者：
Eralp, Y.;Derin, D.;Topuz, E.
背景资料：据估计，三阴性乳腺癌占所有乳腺癌患者的15%-20%，并且被认为是一个在治疗上不利的子集。本研究的目的是评估三阴性乳腺癌患者的各种分子因素的预后影响。患者和方法：从109例受体阴性（雌激素受体和孕激素受体）乳腺癌的肿瘤标本进行了分析丝裂原活化蛋白激酶（MAPK），表皮生长因子受体（EGFR）和磷酸肌醇-3-激酶（PI 3 K）的表达免疫组化。结果：EGFR、MAPK和PI 3 K阳性表达分别为15例（13.8%）、38例（34.9%）和33例（30.3%）。MAPK与蒽环类抗生素耐药相关（P = 0.008），较低的MAPK评分与较短的无病生存期显著相关（P = 0.029）。MAPK评分越高，复发后生存率越低（P = 0.03）。结论：MAPK是三阴性乳腺癌患者的一个重要的预后预测因子。此外，在那些MAPK表达阳性的患者中，染色水平可能在复发的不同阶段发挥预后作用。需要进一步的转化研究来阐明这部分患者肿瘤增殖的分子机制。
Background: Triple-negative breast cancer is estimated to account for 15%-20% of all patients with breast cancer and is considered as a prognostically unfavorable subset. The aim of this study is to evaluate the prognostic impact of various molecular factors in patients with triple-negative breast cancer.Patients and methods: Tumor specimens from 109 patients with receptor-negative (estrogen receptor and progesterone receptor) breast cancer were analyzed for mitogen-activated protein kinase (MAPK), epidermal growth factor receptor (EGFR) and phosphoinositol-3-kinase (PI3K) expression by immunohistochemistry. The prognostic significance of these molecular factors, in addition to various prognostic variables, was investigated.Results: Fifteen (13.8%), 38 (34.9%) and 33 patients (30.3%) had positive staining for EGFR, MAPK and PI3K, respectively. MAPK was associated with anthracycline resistance (P = 0.008) and lower MAPK score was significantly associated with shorter disease-free survival (P = 0.029). Survival following relapse was significantly worse for those with a higher MAPK score (P = 0.03).Conclusion: MAPK is a significant prognostic and predictive factor in patients with triple-negative breast cancer. Furthermore, the level of staining among those with a positive MAPK expression may play a prognostic role at different stages of relapse. Further translational research is required to elucidate molecular mechanisms of tumor proliferation in this subset of patients.