Nuclear receptors and non-alcoholic fatty liver disease: An update
Nuclear receptors and non-alcoholic fatty liver disease: An update
复制标题
DOI：
10.1016/j.livres.2020.03.001
复制
发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
Xiao Yang;F. Gonzalez;Min Huang;H. Bi
中科院分区：
文献类型：
--
作者：
Xiao Yang;F. Gonzalez;Min Huang;H. Bi
非酒精性脂肪肝（NAFLD）已成为全球成人和儿童慢性肝病的主要原因。NAFLD的症状从单纯的脂肪变性和非酒精性脂肪性肝炎（NASH）到肝纤维化或肝硬化，甚至最终发展为肝细胞癌。核受体（Nuclear receptor，NR）是一个配体激活的转录因子超家族，其中大多数是配体激活的，控制肝脏和其他组织中的细胞稳态。越来越多的研究证明了NR在NAFLD中的重要作用。在这篇综述中，目前的研究结果在NAFLD中的作用进行了总结，并讨论了未来的前景，以NAFLD为目标的NR。
Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease in adults and children worldwide. The symptoms of NAFLD range from simple steatosis and non-alcoholic steatohepatitis (NASH) to hepatic fibrosis or cirrhosis, even ultimately develops to hepatocellular carcinoma. Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors, most of which are ligand-activated that control cellular homeostasis in the liver and other tissues. A growing number of studies demonstrated the important role of NRs in NAFLD. In this review, the current findings on the role of NRs in NAFLD are summarized and future perspectives to target NRs for NAFLD are discussed.