Inclusion of an S-nitrosylating agent in the insufflating gas does not alter gastric activity in rats following pneumoperitoneum.
Inclusion of an S-nitrosylating agent in the insufflating gas does not alter gastric activity in rats following pneumoperitoneum.
复制标题
在吹入的气体中包含S-亚硝基化剂不会改变气腹后大鼠的胃活动。
DOI：
10.1007/s00464-006-9107-6
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Reynolds,JD
中科院分区：
文献类型：
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作者：
Shah,MK;Shimazutsu,K;Uemura,K;Takahashi,T;Stamler,JS;Reynolds,JD
背景我们之前已经表明，将S-亚硝基化剂亚硝酸乙酯与二氧化碳混合可以减轻气腹引起的内脏血流减少，但尚不清楚该剂是否会改变胃功能。使用大鼠，通过评估放射性铬灌胃后的胃排空和胃肠道传输时间来回答这个问题。方法有五个实验组：绝对对照组、麻醉对照组、单独二氧化碳或与百万分之100或300的亚硝酸乙酯一起使用二氧化碳。吹气时间为1小时，铬给药后6.5小时对所有动物实施安乐死。结果胃中残留的放射性平均量为总给药量的16%至27%；这些差异不具有统计显着性 (p> 0.05)。在胃肠道中发现铬分布存在适度差异，但对于所有治疗，放射性峰值位于远端部分。峰的位置以占总消化道长度的百分比表示，在 70% 到 85% 之间变化 (p= 0.366)。结论本研究发现亚硝酸乙酯对术后胃排空或气腹后胃肠道通过时间没有不利影响。研究结果支持继续评估亚硝酸乙酯在腹腔镜手术中的临床效用。
BackgroundWe have previously shown that mixing the S-nitrosylating agent ethyl nitrite with carbon dioxide can attenuate pneumoperitoneum-induced decreases in splanchnic blood flow, but it was unclear if this agent would alter gastric function. This question was answered using rats by assessing gastric emptying and gastrointestinal transit times following gavage with radioactive chromium.MethodsThere were five experimental groups: absolute control, anesthesia control, and carbon dioxide alone or with 100 or 300 parts per million ethyl nitrite. The period of insufflation was 1 h, and all animals were euthanized 6.5 h after chromium administration.ResultsThe mean amount of radioactivity remaining in the stomach ranged between 16% and 27% of the total administered; these differences were not statistically significant (p> 0.05). Modest differences in chromium distribution were identified in the gastrointestinal tract, but for all treatments, the peak amount of radioactivity was located in the distal portion. Location of the peak, expressed as a percentage of total tract length, varied between 70% and 85% (p= 0.366).ConclusionsThis study found no adverse effect of ethyl nitrite on postoperative gastric emptying or gastrointestinal transit time following pneumoperitoneum. The findings support continued assessment of the clinical utility of ethyl nitrite in the setting of laparoscopic surgery.