Molecular regulation of satellite cells via intercellular signaling.
Molecular regulation of satellite cells via intercellular signaling.
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DOI：
10.1016/j.gene.2023.147172
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发表时间：
2023-01
期刊：
影响因子：
3.5
通讯作者：
Chung-Ju Yeh;Kristina Marie Sattler;Christoph Lepper
中科院分区：
文献类型：
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作者：
Chung-Ju Yeh;Kristina Marie Sattler;Christoph Lepper
体细胞干细胞是组织特异性的储备细胞，其任务是维持成年期组织稳态和/或影响创伤后组织再生。骨骼肌组织的干细胞是卫星细胞，最初被描述并命名为卫星细胞，因为它们位于肌纤维层下，附着在多核肌纤维上。在成体体内平衡过程中，卫星细胞处于静止状态，这是一种可逆的细胞周期停滞状态。然而，在损伤后，卫星细胞迅速被激活，变得高度有丝分裂活跃，产生大量的成肌细胞，这些成肌细胞分化并融合以再生受损的肌纤维。一个子集自我更新以补充肌肉干细胞库。复杂的内在基因调控网络维持卫星细胞的静止状态，或在损伤时指导其激活、增殖、分化和自我更新。来自卫星细胞环境的分子线索提供了卫星细胞何时何地保持静止或打破静止并影响再生肌发生的基本信息。这些线索主要是分泌的、扩散的或膜结合的配体，它们与卫星细胞上的特定同源受体结合并激活它们，从而激活下游信号级联并引发环境特异性细胞行为。本文综述了静止和损伤诱导的骨骼肌再生过程中调节卫星细胞的主要细胞间信号通路。
Somatic stem cells are tissue-specific reserve cells tasked to sustain tissue homeostasis in adulthood and/or effect tissue regeneration after traumatic injury. The stem cells of skeletal muscle tissue are the satellite cells, which were originally described and named after their localization beneath the muscle fiber lamina and attached to the multi-nucleated muscle fibers. During adult homeostasis, satellite cells are maintained in quiescence, a state of reversible cell cycle arrest. Yet, upon injury, satellite cells are rapidly activated, becoming highly mitotically active to generate large numbers of myoblasts that differentiate and fuse to regenerate the injured muscle fibers. A subset self-renews to replenish the pool of muscle stem cells. Complex intrinsic gene regulatory networks maintain the quiescent state of satellite cells, or upon injury, direct their activation, proliferation, differentiation and self-renewal. Molecular cues from the satellite cells’ environment provide the essential information as to when and where satellite cells are to stay quiescent or break quiescence and effect regenerative myogenesis. Predominantly, these cues are secreted, diffusible or membrane-bound ligands that bind to and activate their specific cognate receptors on the satellite cell to activate downstream signaling cascades and elicit context-specific cell behavior. This review aims to offer a concise overview of major intercellular signaling pathways regulating satellite cells during quiescence and in injury-induced skeletal muscle regeneration.