History and Therapeutic Rationale of Long Acting Antipsychotics
History and Therapeutic Rationale of Long Acting Antipsychotics
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DOI：
10.2174/15748847113089990057
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发表时间：
2014-01-01
影响因子：
3.2
通讯作者：
Lang, Antonella P.
中科院分区：
文献类型：
--
作者：
De Risio, Alessandro;Lang, Antonella P.
尽管长效抗精神病药物被广泛使用，但由于担心惩罚、控制以及由于使用不当而导致的精神病患者对心理社会发展的不充分演变，长效抗精神病药物往往受到偏见。长效抗精神病药物的另一个主要缺点是，如果出现副作用，就不可能改变剂量。然而，由于稳定的剂量给药，长效抗精神病药物被证明对精神分裂症和其他严重的精神障碍有效，从而减少了复发，提高了治疗依从性。近年来，在推出新的长效第二代抗精神病药物后，治疗机会也增加了。开发了较新的长效抗精神病药物，以满足药物治疗的需要，提高综合康复方案的依从性。本文综述了较老的和较新的长效抗精神病药物在精神分裂症和其他精神病治疗中的发展和介绍，并对过去和现在的药理和治疗问题进行了讨论。
Despite their widespread use, long acting antipsychotics, are often regarded with prejudice, due to fears of punishment, control and insufficient evolution towards psychosocial development of psychotic patients raised by their improper utilization. Another major shortcoming of long-acting antipsychotics is the impossibility of altering their dosage if side-effects appear. However, long-acting antipsychotics proved effective in schizophrenia and other severe psychotic disorders as a consequence of stable dose administration, leading to reduction of relapses and increased treatment adherence. Therapeutic opportunities have also risen after introduction of newer long acting second generation antipsychotics in recent years. Newer long-acting antipsychotics were developed to tackle the need for pharmacotherapy enhancing adherence in integrated rehabilitation programmes. This review is an outline of the development and introduction of older and newer long-acting antipsychotics in the treatment of schizophrenia and other psychoses, with considerations on past and present pharmacological and therapeutic issues.