Key clinical research priorities for the pediatric community during the COVID-19 pandemic.
Key clinical research priorities for the pediatric community during the COVID-19 pandemic.
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DOI：
10.1038/s41390-020-0962-y
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发表时间：
2021-03
影响因子：
3.6
通讯作者：
Connor E
中科院分区：
文献类型：
--
作者：
Noel GJ;Davis JM;Ramilo O;Bradley JS;Connor E
截至5月1日，约翰霍普金斯冠状病毒研究中心正在报告，全球已发生312.7万例冠状病毒病19（COVID-19）和213,791例与这些感染相关的死亡病例（https：//coronavirus. jhu。edu/）。随着这一流行病的发展，有关病毒如何影响儿童健康的信息不断得到报告。4月初，美国疾病控制和预防中心计算出，在美国约1.7%（149，082例报告年龄的2，572例）的COVID-19病例发生在18岁以下的儿童中[1]。这些病例中有73%与发热、咳嗽和/或呼吸急促有关，5.7%住院，而成年人分别为93%和10%。儿童病例的中位年龄为11岁（范围为0-17岁），其中33%报告的儿童年龄为15-17岁，15%报告的儿童年龄< 1岁。在这个数据集中，23%的儿童有潜在的医疗状况，77%的住院儿童和所有6名入住ICU的儿童都有这种情况。大流行最初几个月的经验表明，虽然儿童和成人对感染的易感性可能相似，但儿童患严重疾病的风险似乎较低。[1-3]中所述。尽管如此，仍有严重的COVID-19在儿童中报告，包括新生儿/幼儿和有基础疾病的儿童[2，4]。鉴于需要紧急应对这一流行病，儿科医生的当务之急是为那些病情最严重的人提供医疗保健，即使这意味着帮助照顾成人和老年患者。然而，随着大流行的成熟，儿科临床研究界也必须立即开始确定关键的知识差距，并填补这些差距，以最好地满足儿童的需求。尤其是在需要将信息真实的应用于临床的情况下，以告知临床研究，并以我们可能在成人中看到的相同速度推进儿童COVID-19感染相关领域。对儿童来说，有几个关键问题需要紧急准备和行动（表）。
As of May 1 st, the Johns Hopkins Coronavirus Research Center is reporting that 3.127 million cases of coronavirus disease 19 (COVID-19) and 213,791 deaths related to these infections have occurred worldwide ( https://coronavirus. jhu. edu/). As the pandemic evolves, information about how the virus has impacted the health of children is being steadily reported. In early April, the CDC calculated that in the US approximately 1.7%(2,572 of 149,082 for which age was reported) of COVID-19 cases had occurred in children< 18 years of age [1]. Seventy three percent of these cases were associated with fever, cough, and/or shortness of breath and 5.7% were hospitalized, compared to 93% and 10% respectively in adults. The median age of cases in children was 11 years (range 0-17 years) with 33% reported in children 15-17 years of age and 15% in children< 1 year of age. In this dataset, 23% of children had underlying medical conditions which were present in 77% of hospitalized children and all six children admitted to the ICU. The experience in the first months of the pandemic suggests that although susceptibility to infection may be similar in children and adults, the risk for severe disease appears to be lower in children.[1-3]. Nevertheless, serious COVID-19 has been reported in children, including neonates/young infants and those with underlying medical conditions [2, 4]. Given the need to urgently responding to the pandemic, the immediate priority of pediatricians has been to provide healthcare to those most severely ill, even if this means helping care for adult and elderly patients. However, as the pandemic matures, it is also very important for the pediatric clinical research community to start immediately identifying key knowledge gaps and to fill those gaps to best address the needs of children. This is particularly true where information needs to be clinically applied in real time to inform clinical research and advance the field related to COVID-19 infections in children at the same pace we are likely to see for adults. For children, several key issues require urgent preparation and action (Table).
影响因子：
3.6
作者：
Zimmermann, Petra;Curtis, Nigel
通讯作者：
Curtis, Nigel