Single voxel proton MR spectroscopy findings of typical and atypical intracranial meningiomas
Single voxel proton MR spectroscopy findings of typical and atypical intracranial meningiomas
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DOI：
10.1016/j.ejrad.2006.06.002
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发表时间：
2006-10-01
影响因子：
3.3
通讯作者：
Sav, Aydin
中科院分区：
文献类型：
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作者：
Demir, Mustafa Kemal;Iplikcioglu, A. Celal;Sav, Aydin
目的：前瞻性明确脑膜瘤的质子磁共振波谱(MRS)表现，评价短回声和长回声MRS对典型脑膜瘤和不典型脑膜瘤的活体鉴别诊断能力。材料与方法：对17例经手术病理证实的典型脑膜瘤和6例不典型脑膜瘤患者在手术前行常规MR和MRS检查。使用点分辨波谱(PRESS)定位，在短回声时间和长回声时间(TR2000ms，TE：30和144ms，-96采集)的MRS研究在1.5T扫描仪上采集。将从这些患者获得的MRS数据与组织病理学结果进行比较。所有脑膜瘤的平均细胞增殖(MIB-1)抗体染色均为Ki-67抗原。23例脑膜瘤中有21例检测到丙氨酸(ALA)。在长TE(144ms)频谱上，两组脑膜瘤均未观察到或检测到微量的乙酰天冬氨酸(NAA)和肌酸(Cr)。短时TE谱上，4例不典型脑膜瘤Cho/Cr值为4.44+/-0.30(平均标准差)，12例典型脑膜瘤Cho/Cr值为3.39+/-0.52。其余7例因缺乏肌酸峰而无法测定Cho/Cr值。在检测到乳酸峰值的5例脑膜瘤中，4例为典型脑膜瘤，仅1例为不典型脑膜瘤。MIB-1增殖指数在典型脑膜瘤中平均为3.7%，在不典型脑膜瘤中平均为10%。结论：异常脑膜瘤和非典型脑膜瘤在MRS上均表现为明显的CHO、NAA和Cr的缺失或低表达，以及ALA的存在，MRS不能准确地鉴别典型脑膜瘤和不典型脑膜瘤。平均MIB-1增殖指数与组织病理学结果呈正相关。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
Purpose: To prospectively define proton magnetic resonance spectroscopy (MRS) findings of meningiomas, and describe the ability or inability of short- and long-echo MRS to differentiate typical and atypical meningiomas in vivo.Material and methods: Seventeen patients with pathologically confirmed typical meningiomas and six with atypical meningiomas were evaluated with conventional MR imaging and MRS before resection. MRS studies using point-resolved spectroscopy (PRESS) localisation, at short- and long-echo time (TR 2000 ms, TE: 30 and 144 ms, 64-96 acquisition) were acquired on a 1.5 T scanner. MRS data obtained from these patients were compared with histopathological findings. Mean cellular proliferation (MIB-1) antibody staining against the Ki-67 antigen was also determined in all meningiomas.Results: Prominent choline (Cho) was present in all meningiomas. Alanine (Ala) was observed in 21 cases of the 23 meningiomas. Acetylaspartate (NAA) and creatine (Cr) were either not observed or detected in minimal amounts in at all both groups of meningiomas on long TE (144 ms) spectra. The mean Cho/Cr values in the four atypical meningiomas were 4.44 +/- 0.30 (mean standard deviation) and 3.39 +/- 0.52 in the 12 typical meningiomas on short TE spectra. Cho/Cr ratio could not be determined in the other seven cases because of a lack of creatine peak. Of the five meningiomas in which a lactate peak was detected, four were in typical cases and only one was in atypical meningioma. Mean MIB-1 proliferation index was 3.7% in typical meningiomas and 10% in atypical meningiomas.Conclusion: Prominent Cho, absence or low amount of NAA and Cr, and presence of Ala were common characteristics of spectral pattern of both atypical and typical meningiomas on MRS. MRS cannot reliably differentiate typical intracranial meningiomas from atypical meningiomas preoperatively. Mean MIB-1 proliferation index was well correlated with histopathology findings. (C) 2006 Elsevier Ireland Ltd. All rights reserved.