S100B, a neurotropic protein that modulates neuronal protein phosphorylation, is upregulated during lesion-induced collateral sprouting and reactive synaptogenesis.
S100B, a neurotropic protein that modulates neuronal protein phosphorylation, is upregulated during lesion-induced collateral sprouting and reactive synaptogenesis.
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S100B 是一种调节神经元蛋白磷酸化的亲神经蛋白，在损伤诱导的侧枝萌芽和反应性突触发生过程中上调。
DOI：
10.1016/s0006-8993(98)01014-2
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发表时间：
1998
期刊：
影响因子：
2.9
通讯作者：
Norden,JJ
中科院分区：
文献类型：
--
作者：
McAdory,BS;VanEldik,LJ;Norden,JJ
Using light and electron microscopic immunocytochemistry, we examined the expression of the Ca2+-binding protein S100B in the dentate gyrus of adult rats during lesion-induced sprouting and reactive synaptogenesis. Nine days following unilateral lesioning of the entorhinal cortex, S100B was upregulated in cells primarily in the outer part of the molecular layer of the ipsilateral dentate gyrus. When examined with electron microscopy, numerous astrocytes and synapses containing S100B were identified. These data show that during lesion-induced sprouting and reactive synaptogenesis, S100B is upregulated in astrocytes and can be found in pre- and post-synaptic compartments where it might influence neuronal protein phosphorylation.
