Helicobacter pylori Protection Against Reflux Esophagitis
Helicobacter pylori Protection Against Reflux Esophagitis
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DOI：
10.1007/s10620-012-2349-3
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发表时间：
2012-11-01
影响因子：
3.1
通讯作者：
Razjouyan, Hadie
中科院分区：
文献类型：
--
作者：
Ashktorab, Hassan;Entezari, Omid;Razjouyan, Hadie
据报道，幽门螺杆菌的存在与胃食管反流病（GERD）及其并发症之间呈负相关。本研究的目的是确定幽门螺杆菌 (HP) 是否可以预防非裔美国人 (AA) 人群中的 GERD。从 2004 年到 2007 年，我们研究了 2,020 个病例；食管炎（58），胃炎（1,558），食管炎和胃炎（363）和正常对照组（41）。我们收集了他们的病理学和内窥镜检查单位报告。 HP 状态是根据胃活检染色确定的。79% (1,611) 的病例可获得 HP 数据。胃炎患者 HP 阳性频率为 40% (506)，食管炎患者为 4%，正常对照者为 34% (11)，而食管炎和胃炎患者中 HP 阳性率为 34%。调整年龄和性别的影响后，食管炎组与正常组的 HP 优势比为 0.06（95% CI 0.01-0.59；P 值 = 0.01）。我们的结果显示，幽门螺杆菌与 AA 中的食管炎呈显着负相关，这可能表明幽门螺杆菌在食管炎的发病机制中具有保护作用。此外，幽门螺杆菌可能是 AA 中 GERD 并发症较低的原因。
Negative association has been reported between presence of Helicobacter pylori and developing gastroesophageal reflux disease (GERD) and its complications. The aim of this study was to determine whether H. pylori (HP) can be protective against GERD in an African American (AA) population.From 2004 to 2007, we studied 2,020 cases; esophagitis (58), gastritis (1,558), both esophagitis and gastritis (363) and a normal control group (41). We collected their pathology and endoscopy unit reports. HP status was determined based on staining of gastric biopsy.HP data was available for 79 % (1,611) of the cases. The frequency of HP positivity in gastritis patients was 40 % (506), in esophagitis patients 4 % and in normal controls 34 % (11), while HP was positive in 34 % of the patients with both esophagitis and gastritis. After adjusting for effects of age and sex, odds ratio of HP was 0.06 (95 % CI 0.01-0.59; P value = 0.01) for the esophagitis group versus the normal group.Our results show H. pylori has a significant negative association with esophagitis in AAs which may point to a protective role of H. pylori in the pathogenesis of esophagitis. In addition, H. pylori may be the reason for the low GERD complications in AAs.