Ligated Pd-Catalyzed Aminations of Aryl/Heteroaryl Halides with Aliphatic Amines under Sustainable Aqueous Micellar Conditions
Ligated Pd-Catalyzed Aminations of Aryl/Heteroaryl Halides with Aliphatic Amines under Sustainable Aqueous Micellar Conditions
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DOI：
10.1021/jacsau.3c00742
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发表时间：
2024-02-12
期刊：
影响因子：
8
通讯作者：
Lipshutz，Bruce H.
中科院分区：
文献类型：
--
作者：
Iyer，Karthik S.;Kavthe，Rahul D.;Lipshutz，Bruce H.
报道了一种可持续的技术，用于构建Pd催化的脂肪胺C-N键。一个催化系统，依赖于低水平的可回收的贵金属，一个已知的和商业上可获得的配体，和一个可回收的水介质相结合，导致一个新开发的程序。这项新技术可以在海水中使用，同样有效。涉及构成后期官能化的高度挑战性的反应伙伴的应用被记录，因为是药物萘哌地尔的短而有效的合成。与现有胺化的比较突出了所提供的许多进步。
Sustainable technology for constructing Pd-catalyzed C–N bonds involving aliphatic amines is reported. A catalytic system that relies onlow levels of recyclable precious metal, a known andcommercially available ligand, and arecyclable aqueous mediumare combined, leading to a newly developed procedure. This new technology can be used in ocean water with equal effectiveness. Applications involving highly challenging reaction partners constituting late-stage functionalization are documented, as is a short but efficient synthesis of the drug naftopidil. Comparisons with existing aminations highlight the many advances being offered.