Towards a quantitative understanding of the within-host dynamics of influenza A infections
Towards a quantitative understanding of the within-host dynamics of influenza A infections
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DOI：
10.1098/rsif.2009.0067
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发表时间：
2010-01-06
影响因子：
3.9
通讯作者：
Antia, Rustom
中科院分区：
文献类型：
--
作者：
Handel, Andreas;Longini, Ira M., Jr.;Antia, Rustom
虽然甲型流感病毒已被广泛研究，但仍然缺乏对感染动力学的定量了解。为了在这方面取得进展，我们设计了几个数学模型，并将它们与A型流感感染小鼠的数据进行了比较。我们发现，免疫反应（IR）在感染动力学中起着重要的作用。先天和自适应IR都需要提供足够的解释的数据。相反，上皮细胞的再生似乎不是感染时间尺度上的重要机制。我们还发现，先天和适应性反应的不同模型变体很好地拟合了数据，这表明需要额外的数据来进行进一步的模型区分。
Although the influenza A virus has been extensively studied, a quantitative understanding of the infection dynamics is still lacking. To make progress in this direction, we designed several mathematical models and compared them with data from influenza A infections of mice. We find that the immune response (IR) plays an important part in the infection dynamics. Both an innate and an adaptive IR are required to provide adequate explanation of the data. In contrast, regrowth of epithelial cells did not seem to be an important mechanism on the time scale of the infection. We also find that different model variants for both innate and adaptive responses fit the data well, indicating the need for additional data to allow further model discrimination.