REGULATED IMPORT AND DEGRADATION OF A CYTOSOLIC PROTEIN IN THE YEAST VACUOLE
REGULATED IMPORT AND DEGRADATION OF A CYTOSOLIC PROTEIN IN THE YEAST VACUOLE
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DOI：
10.1038/350313a0
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发表时间：
1991-03-28
期刊：
影响因子：
64.8
通讯作者：
SCHEKMAN, R
中科院分区：
文献类型：
--
作者：
CHIANG, HL;SCHEKMAN, R
在糖异生过程中，关键的调节酶果糖 -1,6 - 二磷酸酶（FBPase）在酿酒酵母中会受到葡萄糖刺激而发生蛋白水解降解。这一过程涉及FBPase从细胞质直接转移到液泡或与液泡相关的细胞器，且这种转移是受调控的。葡萄糖可能会调节一种FBPase受体或输入因子的产生，该受体或因子通过分泌途径被运输到液泡。
The key regulatory enzyme in gluconeogenesis, fructose 1,6-bisphosphatase (FBPase) is subject to glucose-stimulated proteolytic degradation in Saccharomyces cerevisiae. This process involves the regulated transfer of FBPase directly from the cytosol into the vacuole or a vacuole-related organelle. Glucose may regulate the production of an FBPase receptor or import factor that is transported to the vacuole through the secretory pathway.