Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy
Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy
复制标题
DOI：
10.1016/j.jns.2015.01.017
复制
发表时间：
2015-02-15
影响因子：
4.4
通讯作者：
Haginoya, Kazuhiro
中科院分区：
文献类型：
--
作者：
Sun, Guilian;Ota, Chiharu;Haginoya, Kazuhiro
我们检测了无并发症流感（n = 20）和流感病毒相关脑病（IE）（n = 18）患者的各种细胞因子、趋化因子、生长因子和粘附分子的血清水平，以了解IE的潜在机制。我们发现，与正常对照组相比，无并发症的流感患者和IE患者的血清中IL-1 β、IL-2、IL-5、IL-6、IL-7、IL-8、IL-10、IL-13、G-CSF、GM-CSF、TNF-α、TIMP-1、MMP-9、sE-选择素和中性粒细胞弹性蛋白酶显著升高（n = 20）。值得注意的是，中性粒细胞弹性蛋白酶，sE-选择素，IL-8和IL-13在IE中与单纯流感相比显著升高。在本研究中，我们首次发现，血清中性粒细胞弹性蛋白酶的水平增加，IE患者相比，简单的流感，这表明，在LE的发展脑内皮损伤是由中性粒细胞弹性蛋白酶介导的。本研究提示抗弹性蛋白酶药物可能是IE的有效治疗方案，但尚需进一步阐明。(C)2015爱思唯尔B. V.保留所有权利。
We examined serum levels of various cytokines, chemoldnes, growth factors, and adhesion molecules in patients with uncomplicated influenza (n = 20) and influenza virus-associated encephalopathy (IE) (n = 18) to understand the underlying mechanism of IE. We found that IL-1 beta, IL-2, IL-5, IL-6, IL-7, IL-8, IL-10, IL-13, G-CSF, GM-CSF, TNF-alpha, TIMP-1, MMP-9, sE-selectin, and neutrophil elastase were elevated significantly in sera from patients with uncomplicated influenza and those with IE, compared with normal controls (n = 20). Of note, neutrophil elastase, sE-selectin, IL-8, and IL-13 were elevated significantly in IE as compared with uncomplicated influenza. In the present study, for the first time, we found that serum levels of neutrophil elastase were increased in patients with IE compared with uncomplicated influenza, which suggested that cerebral endothelial damage in the development of LE was mediated by neutrophil elastase. The present study implied that anti-elastase agents are possibly an effective therapeutic protocol for IE, but this needs further elucidation. (C) 2015 Elsevier B.V. All rights reserved.