Endothelial dysfunction is associated with increased levels of biomarkers in essential hypertension
Endothelial dysfunction is associated with increased levels of biomarkers in essential hypertension
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DOI：
10.1038/jhh.2009.91
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发表时间：
2010-06-01
影响因子：
2.7
通讯作者：
Larrousse, M.
中科院分区：
文献类型：
--
作者：
de la Sierra, A.;Larrousse, M.
为探讨高血压病患者血管内皮功能障碍与血清炎症、重塑和氧化应激标志物水平的相关性，对78例未接受治疗的高血压病患者(平均年龄43岁)进行了血管内皮功能障碍的检测，检测指标包括乙酰胆碱诱导的前臂血管最大舒张率和血清黏附分子、选择素、趋化因子、金属蛋白酶、铜、锌、硒、维生素、同型半胱氨酸、丙二醛、红细胞谷胱甘肽过氧化物酶和红细胞超氧化物歧化酶水平。平均值(+/-S.E.M.)乙酰胆碱诱导的最大血管舒张率为367+/-20%。乙酰胆碱依赖的血管扩张功能受损的患者(第一三分体)的e-选择素(P=0.009)、p-选择素(P
To assess the correlation between endothelial dysfunction and the serum levels of biomarkers of inflammation, remodelling and oxidative stress in essential hypertension, 78 treatment-naive essential hypertensives (mean age 43 years) underwent measurement of endothelial dysfunction, using the maximal acetylcholine-induced forearm vasodilation and serum levels of adhesion molecules, selectins, chemokines, metalloproteinases, copper, zinc, selenium, vitamins, homocysteine, malondialdehyde, erythrocyte glutathione peroxidase and erythrocyte superoxide dismutase. Mean (+/- s.e.m.) maximal acetylcholine-induced vasodilation was 367 +/- 20%. Patients with a more impaired acetylcholine-dependent vasodilation (first tertile) had increased levels of e-selectin (P=0.009), p-selectin (P