Prenatal exposure to mixture of heavy metals, pesticides and phenols and IQ in children at 7 years of age: The SMBCS study
Prenatal exposure to mixture of heavy metals, pesticides and phenols and IQ in children at 7 years of age: The SMBCS study
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DOI：
10.1016/j.envint.2020.105692
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发表时间：
2020-06-01
影响因子：
11.8
通讯作者：
Zhou, Zhijun
中科院分区：
文献类型：
--
作者：
Guo, Jianqiu;Wu, Chunhua;Zhou, Zhijun
目的：产前暴露于重金属，农药和酚类已被认为会干扰神经发育，但其混合物的神经毒性仍不清楚。我们的目的是阐明母亲的尿液中选定的化学混合物的浓度与智商（IQ）在children.Methods：母亲的尿液中选定的重金属，农药代谢物，酚类化合物的浓度进行了量化的孕妇谁参加了射阳微型出生队列研究（SMBCS）从2009年6月至2010年1月。在7岁时，由经过培训的儿科医生使用中文版的韦氏儿童智力量表（C-WISC）对儿童的智商进行评估。采用广义线性回归模型（GLM）、贝叶斯核机器回归模型（BKMR）和弹性网络回归模型（ENR）对7岁儿童的尿中化学物质及其混合物浓度与智商的关系进行了研究。在326对母子中，单化学模型表明，产前尿铅（Pb）和双酚A（BPA）浓度与全面智商（FIQ）呈显著负相关在7岁儿童中[β =-2.31，95%置信区间（CI）：-4.13，-0.48; p = 0.013，性别相互作用p值= 0.076; β =-1.18，95% CI：-2.21，-0.15; p = 0.025;性别相互作用p值= 0.296，分别为铅和双酚A]。按性别进行的分层分析表明，这种关联仅在男孩中具有统计学意义。在多化学BKMR和ENR模型中，产前尿铅水平与男孩7岁时的FIQ评分之间存在统计学显著负相关。此外，BKMR分析表明，当所有化学物质的浓度都在75分之一或更高时，与50分之一时相比，总体混合物与男孩智商下降有关。ENR模型显示，产妇尿铅水平与较低的FIQ分数（β =-2.20，95%CI：-4.20，-0.20，P = 0.031）。结论：产前暴露于选定的化学混合物可能会影响7岁时的智力表现，特别是在男孩。铅和BPA被怀疑是与儿童神经发育有关的主要化学物质。
Objective: Prenatal exposure to heavy metals, pesticides and phenols has been suggested to interfere with neurodevelopment, but the neurotoxicity of their mixtures is still unclear. We aimed to elucidate the associations of maternal urinary concentrations of selected chemical mixtures with intelligence quotient (IQ) in children.Methods: Maternal urinary concentrations of selected heavy metals, pesticide metabolites, and phenols were quantified in pregnant women who participated in the Sheyang Mini Birth Cohort Study (SMBCS) from June 2009 to January 2010. At age 7 years, child's IQ score was assessed using the Chinese version of Wechsler Intelligence Scale for Children (C-WISC) by trained pediatricians. Generalized linear regression models (GLM), Bayesian kernel machine regression (BKMR) models and elastic net regression (ENR) models were used to assess the associations of urinary concentrations individual chemicals and their mixtures with IQ scores of the 7-yearold children.Results: Of 326 mother-child pairs, single-chemical models indicated that prenatal urinary concentrations of lead (Pb) and bisphenol A (BPA) were significantly negatively associated with full intelligence quotient (FIQ) among children aged 7 years [beta = - 2.31, 95% confidence interval (CI): - 4.13, - 0.48; p = 0.013, sex interaction p-value = 0.076;beta = -1.18, 95% CI: - 2.21, - 0.15; p = 0.025; sex interactionp-value = 0.296, for Pb and BPA, respectively]. Stratified analysis by sex indicated that the associations were only statistically significant in boys. In multi-chemical BKMR and ENR models, statistically significant inverse association was found between prenatal urinary Pb level and boy's FIQ scores at 7 years. Furthermore, BKMR analysis indicated that the overall mixture was associated with decreases in boy's IQ when all the chemicals' concentrations were at their 75th percentiles or higher, compared to at their 50th percentiles. ENR models revealed that maternal urinary Pb levels were statistically significantly associated with lower FIQ scores (beta = - 2.20, 95% CI: - 4.20, - 0.20; p = 0.031).Conclusions: Prenatal exposure to selected chemical mixtures may affect intellectual performance at 7 years of age, particularly in boys. Pb and BPA were suspected as primary chemicals associated with child neurodevelopment.