INFLUENCE OF SMOKING, BODY-FAT DISTRIBUTION, AND ALCOHOL-CONSUMPTION ON SERUM-LIPIDS, LIPOPROTEINS, AND APOLIPOPROTEINS IN EARLY POSTMENOPAUSAL WOMEN
INFLUENCE OF SMOKING, BODY-FAT DISTRIBUTION, AND ALCOHOL-CONSUMPTION ON SERUM-LIPIDS, LIPOPROTEINS, AND APOLIPOPROTEINS IN EARLY POSTMENOPAUSAL WOMEN
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DOI：
10.1016/0021-9150(90)90096-2
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发表时间：
1990-10-01
期刊：
影响因子：
5.3
通讯作者：
CHRISTIANSEN, C
中科院分区：
文献类型：
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作者：
HAARBO, J;HASSAGER, C;CHRISTIANSEN, C
研究了148例绝经早期妇女的吸烟、饮酒、肥胖和体脂分布（直接用双光子吸收法测量腹部脂肪%（AF%）或腰臀比值（WTH））对血脂、脂蛋白和载脂蛋白的影响。所有的女性都很健康，没有人服用已知会影响研究参数的药物。吸烟组甘油三酯、低密度脂蛋白胆固醇（LDL-C）和载脂蛋白B水平显著高于对照组（P < 0.05），LDL-C/HDL-C和载脂蛋白B/A-I比值显著高于对照组（P < 0.01），而高密度脂蛋白胆固醇（HDL-C）和载脂蛋白A-I水平显著低于对照组（P < 0.01）。适量饮酒与HDL-C、载脂蛋白A-I呈正相关（P < 0.001）。体重和体重指数（BMI）往往与致动脉粥样硬化脂蛋白和载脂蛋白谱呈正相关。然而，体脂分布参数（AF%和WTH）是脂蛋白和载脂蛋白的较强预测因子，而体重和BMI似乎不是脂蛋白和载脂蛋白的独立预测因子。我们的结论是，吸烟和中央脂肪分布有一个显着的，独立的，对脂质，脂蛋白和载脂蛋白的负面影响，而适度饮酒对这些参数在绝经后早期妇女有积极的影响。
The impact of smoking, alcohol consumption, obesity, and body fat distribution (measured either directly by dual photon absorptiometry as abdominal fat% (AF%) or as the waist-to-hip ratoi (WTH)) on serum lipids, lipoproteins, and apolipoproteins was investigated in 148 early postmenopausal women. All the women were healthy and none were taking medication known to influence the parameters studied. Smokers had significantly higher levels of triglycerides, low density lipoprotein cholesterol (LDL-C), and apolipoprotein B (P < 0.05), and higher ratios of LDL-C/HDL-C and apolipoprotein B/A-I (P < 0.01), but lower levels of high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (P < 0.01). Moderate alcohol consumption was positively associated with HDL-C and apolipoprotein A-I (P < 0.001). Body weight and body mass index (BMI) tended to be positively associated with an atherogenic lipoprotein and apolipoprotein profile. However, body fat distribution parameters (AF% and WTH) were stronger predictors of lipoproteins and apolipoproteins than were body weight and BMI, which did not seem to be independent predictors of lipoproteins and apolipoproteins. We conclude that cigarette smoking and a central fat distribution have a significant, independent, negative influence on lipids, lipoproteins, and apolipoproteins, whereas moderate alcohol consumption has a positive effect on these parameters in early postmenopausal women.