Extracellular Inorganic Phosphate-Induced Release of Reactive Oxygen Species: Roles in Physiological Processes and Disease Development.
Extracellular Inorganic Phosphate-Induced Release of Reactive Oxygen Species: Roles in Physiological Processes and Disease Development.
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DOI：
10.3390/ijms22157768
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发表时间：
2021-07-21
影响因子：
5.6
通讯作者：
Meyer-Fernandes JR
中科院分区：
文献类型：
--
作者：
Lacerda-Abreu MA;Meyer-Fernandes JR
无机磷(PI)是生物体必需的营养物质，在0.8-1.4 mMPI范围内保持平衡。PI是DNA、RNA和磷脂的有机成分的来源，主要通过能量代谢或细胞信号调节器对ATP的形成至关重要。在分离自大脑、肝脏和心脏的线粒体中，PI被证明可以诱导线粒体活性氧物种(ROS)的释放。因此，本文的目的是收集PI诱导的活性物种(主要是ROS)产生的相关实验记录，以考察它们在生理过程中的重要作用，如骨和软骨的发育以及心血管疾病、糖尿病、肌肉萎缩和男性生殖系统损伤等疾病的发生。有趣的是，在不同的抗氧化剂或细胞质和线粒体PI转运体的抑制剂存在下，PI诱导的ROS产生可以被逆转，这可能是一个可能的药理靶点。
Inorganic phosphate (Pi) is an essential nutrient for living organisms and is maintained in equilibrium in the range of 0.8–1.4 mM Pi. Pi is a source of organic constituents for DNA, RNA, and phospholipids and is essential for ATP formation mainly through energy metabolism or cellular signalling modulators. In mitochondria isolated from the brain, liver, and heart, Pi has been shown to induce mitochondrial reactive oxygen species (ROS) release. Therefore, the purpose of this review article was to gather relevant experimental records of the production of Pi-induced reactive species, mainly ROS, to examine their essential roles in physiological processes, such as the development of bone and cartilage and the development of diseases, such as cardiovascular disease, diabetes, muscle atrophy, and male reproductive system impairment. Interestingly, in the presence of different antioxidants or inhibitors of cytoplasmic and mitochondrial Pi transporters, Pi-induced ROS production can be reversed and may be a possible pharmacological target.
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影响因子：
0.2
作者：
Banjoko, S. Olatunbosun;Adeseoiu, Fasiu O.
通讯作者：
Adeseoiu, Fasiu O.
DOI：
10.1097/01.asn.0000081663.52165.66
发表时间：
2003-09-01
影响因子：
13.6
作者：
Giachelli, CM
通讯作者：
Giachelli, CM
DOI：
10.1016/j.beem.2018.06.004
发表时间：
2018-10-01
影响因子：
7.4
作者：
Christov, Marta;Juppner, Harald
通讯作者：
Juppner, Harald
影响因子：
13.6
作者：
Kestenbaum, B;Sampson, JN;Andress, DL
通讯作者：
Andress, DL
DOI：
10.18632/aging.103896
发表时间：
2020-11-02
期刊：
Aging
影响因子：
--
作者：
Chung LH;Liu ST;Huang SM;Salter DM;Lee HS;Hsu YJ
通讯作者：
Hsu YJ