FEMALE RATS ARE MORE SUSCEPTIBLE TO THE DEVELOPMENT OF NEUROPATHIC PAIN USING THE PARTIAL SCIATIC-NERVE LIGATION (PSNL) MODEL
FEMALE RATS ARE MORE SUSCEPTIBLE TO THE DEVELOPMENT OF NEUROPATHIC PAIN USING THE PARTIAL SCIATIC-NERVE LIGATION (PSNL) MODEL
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DOI：
10.1016/0304-3940(95)11304-f
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发表时间：
1995-02-17
影响因子：
2.5
通讯作者：
MASCARI, C
中科院分区：
文献类型：
--
作者：
COYLE, DE;SEHLHORST, CS;MASCARI, C
进行了一项比较研究，以确定使用动物模型是否可以检测到性别差异。坐骨神经被紧紧地结扎着所以1/3到1/2的神经厚度被结扎住了，就在离坐骨总神经的后二头肌半腱肌神经分支很远的地方。通过测量Von Frey纤维对无害刺激的爪子退出，与假手术或未手术的对照动物（22-24天）相比，显示受伤爪子平均机械敏感性显著提高的大鼠百分比为雄性组的28.6%，而雌性组为63.6%。我们的动物在对足底表面加热的戒断潜伏期中没有表现出一致的反应（超感）。数据表明，雌性大鼠比雄性大鼠更容易发生神经性疼痛。
A comparison study was conducted to determine if a gender difference could be detected using an animal model for causalgia. The sciatic nerve was tightly ligated so that 1/3 to 1/2 of the nerve thickness was trapped by the ligature, just distal to the point at which the posterior biceps semitendinosus nerve branches off the common sciatic nerve. By measuring paw withdrawal from innocuous stimulation with Von Frey filaments, the percent of rats displaying average mechanical sensitivity of the injured paw that was significantly elevated compared to sham or unoperated control animals (days 22-24) was 28.6% for the male group versus 63.6% for the female group. Our animals did not display a consistent response in withdrawal latency to heat applied to the plantar surface of the foot (hyperpathia). The data suggests that female rats are significantly more susceptible to developing neuropathic pain than male rats using this experimental model for causalgia.