Alcohol Drinking Without Meals Is Associated With Risk of Gastrointestinal Cancers, Including Early-Onset Cases.
Alcohol Drinking Without Meals Is Associated With Risk of Gastrointestinal Cancers, Including Early-Onset Cases.
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不进餐饮酒与胃肠道癌症（包括早发病例）的风险相关。
DOI：
10.1053/j.gastro.2023.11.012
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发表时间：
2024
期刊：
影响因子：
29.4
通讯作者：
Cao,Yin
中科院分区：
文献类型：
--
作者：
Shi,Mengyao;Ahmedin,NadiaJ;Zong,Xiaoyu;Yilmaz,ӦmerH;Bishehsari,Faraz;Cao,Yin
在全球范围内，胃肠道(GI)癌症约占新诊断癌症病例的27%，占癌症死亡人数的37%。1有趣的是，在过去的几十年里，在50岁或55岁以下的成年人中，几种胃肠道癌症(非贲门癌、胰腺癌和结直肠癌)的发病率一直呈上升趋势。2饮酒是一种在全球普遍存在的行为，也是食道鳞癌、肝癌和结直肠癌的致病风险因素，也越来越多地被认为是胃癌、胰腺癌和胆囊癌的潜在风险因素。3大多数研究都集中在饮酒量上，往往强调剂量-反应关系4；很少有数据探讨饮酒时机对胃肠道癌症的影响。最近，饮酒前不吃饭在年轻人中越来越受欢迎，以节省卡路里和避免体重增加。然而，这种当代饮酒模式对胃肠道癌症风险的独立影响还没有被调查。我们前瞻性地评估了英国生物库(2006-2021年)中347,591名当前饮酒者中不吃饭饮酒与胃肠道癌症风险之间的关系，这是一个公认的纵向队列，详细评估了饮酒总量和饮酒模式与用餐时间的关系。我们还检查了诊断年龄(较早发病[55岁]与较晚发病[≥55岁])之间的关系。用COX模型估计相对危险度(RR)和95%可信区间(CI)。补充资料中提供了详细的方法。
Globally, gastrointestinal (GI) cancers account for about 27% of newly diagnosed cancer cases and 37% of cancer deaths. 1 Intriguingly, there has been an upward trend in the incidence of several GI cancers (gastric noncardia, pancreatic, and colorectal cancer) among adults younger than 50 or 55 years over the past several decades. 2 Alcohol drinking, a pervasive behavior across the globe and a causal risk factor for esophageal squamous cell carcinoma, liver cancer, and colorectal cancer, is also gaining recognition as a potential risk factor for gastric, pancreatic, and gallbladder cancers. 3 Most studies have focused on the amount of alcohol, often highlighting the dose–response relationship 4; there are scarce data exploring the effect of timing of drinking on GI cancer. Recently, skipping meals before drinking has been gaining popularity among young adults to save calories and avoid weight gain. However, the independent impact of such contemporary drinking patterns on the risk of GI cancers, especially those of early onset, has not been investigated.We prospectively evaluated the association between drinking without meals and risk of GI cancers among 347,591 current drinkers in the UK Biobank (2006–2021), a well-established longitudinal cohort with detailed assessment on the total amount of alcohol intake and drinking pattern relative to mealtimes. We also examined the associations by age of diagnosis (earlier-onset [< 55 years] vs later-onset [≥ 55 years]). Cox models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs). Detailed methods are provided in the Supplementary Materials.