Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate - Comparison study in an elderly population
Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate - Comparison study in an elderly population
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DOI：
10.2337/dc07-0637
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发表时间：
2007-09-01
期刊：
影响因子：
16.2
通讯作者：
Zoli, Marco
中科院分区：
文献类型：
--
作者：
Muscari, Antonio;Antonelli, Serafina;Zoli, Marco
目的-本研究旨在确定一些炎症标志物与胰岛素抵抗的相对相关性。研究设计和方法 - 四种炎症标志物（白细胞计数、红细胞沉降率 [ESR]、高敏 C 反应蛋白 [CRP] 和 C3 补体）被评估为稳态模型评估 (HOMA) 指数的可能决定因素，以及代谢综合征的五个要素（国家胆固醇教育计划成人高胆固醇检测、评估和治疗专家组 [成人治疗小组] III] 定义）、总胆固醇、体力活动和四项肥胖指标（BMI、腰围、体脂百分比和肝脂肪变性）在未经选择的 990 名 65-91 岁受试者群体中进行（皮亚诺罗研究）。 结果 - 在单变量分析中，C3、CRP 和白细胞计数（但不是 ESR）与 HOMA 指数显着相关。在多变量分析中，C3 仍然与胰岛素抵抗相关，其部分 R-2 值最高 (0.049)，独立于所有其他协变量。 HOMA 指数的其他最显着（P < 0.0001）决定因素是总胆固醇 2 2 2 = 0.022）（负相关，R-2 = 0.026）、腰围（R-2 = 0.023）、甘油三酯（R-2 和肝脂肪变性（R-2 = 0.021）（整个模型的 R-2 = 0.450）。炎症标志物处于高位的受试者相对于具有较低值的受试者，调整后的代谢综合征相对风险为（患病率 [95% CI]）：C3 为 1.77（1.41-2.22），白细胞计数为 1.38（1.12-1.70），CRP 为 1.17（0.94-1.46），以及 1.13 ESR (0.91-1.40)。 结论 - 在我们老年人群中同时评估的四种炎症标志物中，只有 C3 与胰岛素抵抗密切相关，与代谢综合征的组成部分以及腹部和全身肥胖的主要指标无关。
OBJECTIVE - This study was performed to ascertain the relative relevance of some inflammatory markers in insulin resistance. RESEARCH DESIGN ANDMETHODS - Four inflammatory markers (leukocyte count, erythrocyte sedimentation rate [ESR], high-sensitivity C-reactive protein [CRP], and C3 complement) were assessed as possible determinants of the homeostasis model assessment (HOMA) index, together with the five elements of the metabolic syndrome (National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults [Adult Treatment Panel III] definition), total cholesterol, physical activity, and four indicators of adiposity (BMI, waist circumference, percent body fat, and hepatic steatosis) in an unselected population of 990 subjects aged 65-91 years (the Pianoro Study).RESULTS - in univariable analysis, C3, CRP, and leukocyte count, but not ESR, were Significantly correlated with HOMA index. In multivariable analysis, C3 remained associated with insulin resistance with the highest partial R-2 value (0.049), independently of all other covariates. The other most significant (P < 0.0001) determinants of HOMA index were total cholesterol 2 2 2 = 0.022), (inverse association, R-2 = 0.026), waist circumference (R-2 = 0.023), triglycerides (R-2 and hepatic steatosis (R-2 = 0.021) (R-2 = 0.450 for the whole model). The adjusted relative risks of having the metabolic syndrome for the subjects with inflammatory markers in the high tertile, with respect to those with lower values, were (prevalence ratio [95% CI]): 1.77 (1.41-2.22) for C3, 1.38 (1.12-1.70) for leukocyte count, 1.17 (0.94-1.46) for CRP, and 1.13 (0.91-1.40) for ESR.CONCLUSIONS - Of the four inflammatory markers simultaneously assessed in our elderly population, only C3 was strongly associated with insulin resistance, independently of the components of the metabolic syndrome and the main indexes of abdominal and general obesity.