A synergistic effect of glucocorticoids and insulin on the differentiation of myoblasts
A synergistic effect of glucocorticoids and insulin on the differentiation of myoblasts
复制标题
糖皮质激素和胰岛素对成肌细胞分化的协同作用
DOI：
10.1002/jcp.1041020105
复制
发表时间：
1980
影响因子：
5.6
通讯作者：
B. D. Sanwal
中科院分区：
文献类型：
--
作者：
E. Ball;B. D. Sanwal
糖皮质激素和胰岛素被发现协同作用，以促进分化的L 6大鼠成肌细胞系的一些克隆。研究了其他激素对这些细胞的影响，以确定协同作用的程度。糖转运的胰岛素刺激不受糖皮质激素的影响，虽然他们本身略有增强运输。糖皮质激素被发现能增加细胞的存活率--这种作用不受胰岛素的影响。环磷酸腺苷水平被发现达到峰值之前的融合和胰岛素的发病时间扩大了这个峰值，而这两种激素的组合进一步延长了环磷酸腺苷水平保持升高的时间。
Glucocorticoids and insulin were found to act synergistically to promote differentiation in some clones of the L6 rat myoblast cell line. Other hormone effects on these cells were investigated to determine the extent of the synergism. The insulin stimulation of sugar transport was unaffected by glucocorticoids although they did by themselves slightly enhance transport. Glucocorticoids were found to increase the adhesiveness of the cells–an effect not influenced by insulin. Cyclic AMP levels were found to peak just prior to the time of the onset of fusion and insulin broadened this peak, while the combination of both hormones further lengthened the time for which cyclic AMP levels remained elevated.