Old and New Roles and Evolving Complexities of Cardiovascular Clocks
Old and New Roles and Evolving Complexities of Cardiovascular Clocks
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发表时间：
2019-06
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通讯作者：
Yanyan Xu;W. Pi;R. Rudic
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作者：
Yanyan Xu;W. Pi;R. Rudic
心血管（CV）系统已被证实受到昼夜节律分子成分的显着影响。昼夜节律的振荡发生在循环系统内，影响血栓形成和血压，以及发生在心血管组织（包括动脉、心脏和肾脏）内，以控制功能。昼夜节律的生理和分子振荡已通过关键核心时钟信号（例如 Bmal1、Period 和 Clock）的全局、组织特异性和转基因报告小鼠模型紧密相连，这些信号可以通过其突变产生病理学和保护作用。随着心血管系统研究中不断出现心血管时钟作用的不同细微差别，新旧小鼠模型系统观察中都提出了新问题，强调了心血管疾病中生物钟机制的重要性、复杂性和持续研究。
The cardiovascular (CV) system has been established to be significantly influenced by the molecular components of circadian rhythm. Oscillations of circadian rhythm occur within the circulation to affect thrombosis and blood pressure and within CV tissues including arteries, heart, and kidney to control function. Physiologic and molecular oscillations of circadian rhythm have been well connected via global, tissue-specific, and transgenic reporter mouse models of key core clock signals such as Bmal1, Period, and Clock, which can produce both pathology and protection with their mutation. With different nuances of CV clock action continuing to emerge in studies of the cardiovascular system, new questions are raised in both new and old mouse model system observations that underscore the importance, complexity, and continued study of the circadian clock mechanism in cardiovascular disease.