Neural differences underlying face processing in veterans with TBI and co-occurring TBI and PTSD
Neural differences underlying face processing in veterans with TBI and co-occurring TBI and PTSD
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DOI：
10.1016/j.jad.2017.07.003
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发表时间：
2017-12-01
影响因子：
6.6
通讯作者：
Simmons, A. N.
中科院分区：
文献类型：
--
作者：
Bomyea, J.;Matthews, S. C.;Simmons, A. N.
背景：创伤性脑损伤（TBI）在军事人员中很常见，并且与创伤后应激障碍（PTSD）的高发病率相关。TBI影响广泛分布的神经模式，其中一些影响情感处理。更好地了解创伤性脑损伤和创伤后应激障碍/创伤性脑损伤如何改变情感神经活动可能会提高我们的理解comorbidity机制，但迄今为止，在这些群体的情绪处理的神经相关性相对understudied.Methods：军事控制，军事人员与创伤性脑损伤的历史，和军事人员与创伤性脑损伤和创伤后应激障碍（N = 53）完成了情绪面部处理任务，在功能磁共振成像。在任务条件下的全脑激活和功能连接进行了比较groups.Results：几个全脑组的差异出现在计划成对的对比，虽然TBI组显示出一些领域的hypoactivation相对于其他组在处理的面孔与形状。与对照组和TBI组相比，PTSD/TBI组表现出杏仁核和杏仁核区域以及一些前额叶和后扣带回区域之间更大的连通性。局限性：尚未建立对其他患者组（包括仅患有PTSD的患者组）的可推广性。在处理面部与形状的条件下，单独的TBI与低激活相关，而PTSD合并TBI与杏仁核、扣带回和前额叶区之间的功能连接改变有关。不同群体之间的连接模式改变表明，PTSD/TBI患者可能需要增加与岛的额叶连接，以实现类似的基于任务的活动。
Background: Traumatic brain injury (TBI) is common in military personnel and associated with high rates of posttraumatic stress disorder (PTSD). TBI impacts widely-distributed neural patterns, some of which influence affective processing. Better understanding how TBI and PTSD/TBI alters affective neural activity may improve our understanding of comorbidity mechanisms, but to date the neural correlates of emotional processing in these groups has been relatively understudied.Methods: Military controls, military personnel with a history of TBI, and military personnel with both TBI and PTSD (N = 53) completed an emotional face processing task during fMRI. Whole-brain activation and functional connectivity during task conditions were compared between groups.Results: Few whole-brain group differences emerged in planned pairwise contrasts, though the TBI group showed some areas of hypoactivation relative to other groups during processing of faces versus shapes. The PTSD/TBI group compared to the control and TBI groups demonstrated greater connectivity between the amygdala and insula seed regions and a number of prefrontal and posterior cingulate regions.Limitations: Generalizability to other patient groups, including those with only PTSD, has not yet been established.Conclusion: TBI alone was associated with hypoactivation during a condition processing faces versus shapes, but PTSD with TBI was associated altered functional connectivity between amygdala and insula regions and cingulate and prefrontal areas. Altered connectivity patterns across groups suggests that individuals with PTSD/TBI may need to increase frontal connectivity with the insulae in order to achieve similar task-based activity.