CLONALITY ANALYSIS OF CHILDHOOD ALL IN REMISSION - NO EVIDENCE OF CLONAL HEMATOPOIESIS
CLONALITY ANALYSIS OF CHILDHOOD ALL IN REMISSION - NO EVIDENCE OF CLONAL HEMATOPOIESIS
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DOI：
10.1016/0145-2126(94)90121-x
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发表时间：
1994-02-01
影响因子：
2.7
通讯作者：
GILLILAND, DG
中科院分区：
文献类型：
--
作者：
BUSQUE, L;ILARIA, R;GILLILAND, DG
We studied 98 female patients in remission (2-240 months) from childhood ALL to determine the clonality status of their hematopoiesis. Thirty-one (31.6%) were heterozygous at the PGK locus for the BstX1 endonuclease restriction site, permitting X-linked clonality assays to be performed. Two patients were in relapse at the time of study and were excluded. We used the PGK-PCR clonality assay (PPCA) to analyze DNA from PMN and mononuclear cells of the remaining 29 female patients. All (29/29) patients demonstrated polyclonal hematopoiesis. These data show that remission from childhood ALL involves reestablishment of polyclonally derived hematopoiesis in all patients studied.
